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Mouse Anti-ORC2 Antibody (ORC2) (CBMAB-0909-YC)


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Summary

Host Animal
Mouse
Specificity
C. elegans
Clone
ORC2
Antibody Isotype
IgG1
Application
IF, WB

Basic Information

Immunogen
Recombinant His6-tagged ORC-2 fusion protein
Specificity
C. elegans
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Origin Recognition Complex Subunit 2
Introduction
ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC2 (origin recognition complex subunit 2) is component of the origin recognition complex (ORC) that binds origins of replication.
Entrez Gene ID
174676
UniProt ID
Q21037
Alternative Names
orc-2; Origin recognition complex subunit 2
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.
Biological Process
DNA replication initiationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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