Mouse Anti-NUCB1 Recombinant Antibody (1H8-2C11) (CBMAB-A6167-LY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1H8-2C11

Antibody Isotype

IgG1, κ

Application

WB, ELISA

Basic Information

Immunogen

NUCB1 (AAH02356, 28 a.a. ~ 461 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

nucleobindin 1

Entrez Gene ID

4924

UniProt ID

Q02818

Alternative Names

DKFZp686A15286; FLJ40471; NUC

Function

Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity).
Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity).

Biological Process

Small GTPase mediated signal transductionISS:UniProtKB

Cellular Location

Golgi apparatus, cis-Golgi network membrane
Cytoplasm
Secreted
A small fraction of the protein may be cytoplasmic.

PTM

O-glycosylated.

More Infomation

References

Zhang, Y., Zhang, G., Zhong, J., Li, A., Wu, Y., & Guo, Z. (2023). Expression and correlation of COX-2 and NUCB1 in colorectal adenocarcinoma. PeerJ, 11, e15774.

Hua, Y. Q., Zhang, K., Sheng, J., Ning, Z. Y., Li, Y., Shi, W. D., & Liu, L. M. (2021). NUCB1 suppresses growth and shows additive effects with gemcitabine in pancreatic ductal adenocarcinoma via the unfolded protein response. Frontiers in Cell and Developmental Biology, 9, 641836.

Yuan, D., Zhang, X., Wang, B., Tang, T., Lei, L., Deng, X., ... & Li, Z. (2020). Effects of feeding status on nucb1 and nucb2A mRNA expression in the hypothalamus of Schizothorax davidi. Fish physiology and biochemistry, 46, 1139-1154.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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