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Mouse Anti-NME1 Antibody (9BA18) (CBMAB-1461CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9BA18
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NME/NM23 Nucleoside Diphosphate Kinase 1
Introduction
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Diseases associated with NME1 include Neuroblastoma and Larynx Cancer. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Metabolism.
Entrez Gene ID
4830
UniProt ID
P15531
Alternative Names
NME1; AWD; GAAD; NDPK-A; NDPKA; NM23; NM23-H1; nm23-H1
Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Biological Process
Cell differentiationIEA:UniProtKB-KW
CTP biosynthetic processIEA:InterPro
EndocytosisIEA:UniProtKB-KW
GTP biosynthetic processIEA:InterPro
LactationIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Positive regulation of DNA bindingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentIMP:HGNC-UCL
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
UTP biosynthetic processIEA:InterPro
Cellular Location
Cytoplasm
Nucleus
Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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