Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-MMP10 Recombinant Antibody (CBXS-0043) (CBMAB-S3044-CQ)


See all MMP10 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0043
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Matrix Metalloproteinase 10
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
matrix metallopeptidase 10
Introduction
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11.
Entrez Gene ID
4319
UniProt ID
P09238
Alternative Names
Matrix Metallopeptidase 10; Matrix Metalloproteinase 10 (Stromelysin 2); Matrix Metalloproteinase-10; MMP-10; STMY2; SL-2; Matrix Metalloprotease 10;
Function
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
Biological Process
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Proteolysis Source: ProtInc
Cellular Location
Extracellular matrix
More Infomation

Ishimura, T., Ishii, A., Yamada, H., Osaki, K., Toda, N., Mori, K. P., ... & Yokoi, H. (2023). Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFκΒ pathway inhibition. Kidney International, 104(5), 929-942.

Abasheva, D., Dolcet-Negre, M. M., Fernández-Seara, M. A., Mora-Gutiérrez, J. M., Orbe, J., Escalada, F. J., & Garcia-Fernandez, N. (2022). Association between Circulating Levels of 25-Hydroxyvitamin D3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes. Nutrients, 14(17), 3484.

Sun, X., & Liu, Y. (2022). Matrix metalloproteinase-10 in kidney injury repair and disease. International Journal of Molecular Sciences, 23(4), 2131.

Fonseca‐Camarillo, G., Furuzawa‐Carballeda, J., Martínez‐Benitez, B., Barreto‐Zuñiga, R., & Yamamoto‐Furusho, J. K. (2021). Increased expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and MMP10, MMP23 in inflammatory bowel disease: cross‐sectional study. Scandinavian Journal of Immunology, 93(1), e12962.

Kudelski, J., Młynarczyk, G., Gudowska-Sawczuk, M., Mroczko, B., Darewicz, B., Bruczko-Goralewska, M., ... & Romanowicz, L. (2021). Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma. Journal of Clinical Medicine, 10(16), 3683.

Zuo, Y., Wang, C., Sun, X., Hu, C., Liu, J., Hong, X., ... & Liu, Y. (2021). Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria. Kidney International, 100(4), 837-849.

Matilla, L., Roncal, C., Ibarrola, J., Arrieta, V., García-Peña, A., Fernández-Celis, A., ... & López-Andrés, N. (2020). A role for MMP-10 (matrix metalloproteinase-10) in calcific aortic valve stenosis. Arteriosclerosis, thrombosis, and vascular biology, 40(5), 1370-1382.

Razai, A. S., Eckelman, B. P., & Salvesen, G. S. (2020). Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody. Journal of Biological Chemistry, 295(8), 2464-2472.

Lv, Y. P., Cheng, P., Zhang, J. Y., Mao, F. Y., Teng, Y. S., Liu, Y. G., ... & Zhuang, Y. (2019). Helicobacter pylori–induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis. Science advances, 5(4), eaau6547.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MMP10 Recombinant Antibody (CBXS-0043)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry