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Rabbit Anti-MMP10 Recombinant Antibody (CBFYM-2347) (CBMAB-M2533-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
CBFYM-2347
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant protein
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
matrix metallopeptidase 10
Introduction
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases. Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11.
Entrez Gene ID
Human4312
Rat117061
UniProt ID
HumanP09238
RatP07152
Alternative Names
Matrix Metallopeptidase 10; Matrix Metalloproteinase 10 (Stromelysin 2); Matrix Metalloproteinase-10; MMP-10; STMY2; SL-2; Matrix Metalloprotease 10
Function
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
Biological Process
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Proteolysis Source: ProtInc
Cellular Location
Extracellular matrix
More Infomation

Ishimura, T., Ishii, A., Yamada, H., Osaki, K., Toda, N., Mori, K. P., ... & Yokoi, H. (2023). Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFκΒ pathway inhibition. Kidney International, 104(5), 929-942.

Abasheva, D., Dolcet-Negre, M. M., Fernández-Seara, M. A., Mora-Gutiérrez, J. M., Orbe, J., Escalada, F. J., & Garcia-Fernandez, N. (2022). Association between Circulating Levels of 25-Hydroxyvitamin D3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes. Nutrients, 14(17), 3484.

Sun, X., & Liu, Y. (2022). Matrix metalloproteinase-10 in kidney injury repair and disease. International Journal of Molecular Sciences, 23(4), 2131.

Fonseca‐Camarillo, G., Furuzawa‐Carballeda, J., Martínez‐Benitez, B., Barreto‐Zuñiga, R., & Yamamoto‐Furusho, J. K. (2021). Increased expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and MMP10, MMP23 in inflammatory bowel disease: cross‐sectional study. Scandinavian Journal of Immunology, 93(1), e12962.

Kudelski, J., Młynarczyk, G., Gudowska-Sawczuk, M., Mroczko, B., Darewicz, B., Bruczko-Goralewska, M., ... & Romanowicz, L. (2021). Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma. Journal of Clinical Medicine, 10(16), 3683.

Zuo, Y., Wang, C., Sun, X., Hu, C., Liu, J., Hong, X., ... & Liu, Y. (2021). Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria. Kidney International, 100(4), 837-849.

Matilla, L., Roncal, C., Ibarrola, J., Arrieta, V., García-Peña, A., Fernández-Celis, A., ... & López-Andrés, N. (2020). A role for MMP-10 (matrix metalloproteinase-10) in calcific aortic valve stenosis. Arteriosclerosis, thrombosis, and vascular biology, 40(5), 1370-1382.

Razai, A. S., Eckelman, B. P., & Salvesen, G. S. (2020). Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody. Journal of Biological Chemistry, 295(8), 2464-2472.

Lv, Y. P., Cheng, P., Zhang, J. Y., Mao, F. Y., Teng, Y. S., Liu, Y. G., ... & Zhuang, Y. (2019). Helicobacter pylori–induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis. Science advances, 5(4), eaau6547.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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