Rabbit Anti-LY75 Recombinant Antibody (R18-D) (CBMAB-C12029-LY)

See all LY75 antibodies

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Summary

Host Animal

Rabbit

Specificity

Human

Clone

R18-D

Antibody Isotype

IgG

Application

IHC-F/IHC-P

Basic Information

Immunogen

Human

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

lymphocyte antigen 75

Entrez Gene ID

4065

UniProt ID

O60449

Function

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity).
Causes reduced proliferation of B-lymphocytes.

Biological Process

EndocytosisIEA:UniProtKB-KW
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Membrane

Topology

Extracellular: 28-1666
Helical: 1667-1691
Cytoplasmic: 1692-1722

PTM

N-glycosylated.

More Infomation

References

Wang, S. S., Zhai, G. Q., Huang, Z. G., Luo, J. Y., He, J., Huang, J. Z., ... & Chen, G. (2023). Nitidine chloride regulates cell function of bladder cancer in vitro through downregulating L ymphocyte antigen 75. Naunyn-Schmiedeberg's Archives of Pharmacology, 1-15.

Gil, M., & Kim, K. E. (2020). Systematic multiomic analysis of Ly75 gene expression and its prognostic value through the infiltration of natural killer (NK) cells in skin cutaneous melanoma. Journal of Clinical Medicine, 9(5), 1383.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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