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Mouse Anti-LRIG1 Recombinant Antibody (CBYJL-1954) (CBMAB-L2021-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeats And Immunoglobulin Like Domains 1 (LRIG1). The antibody can be used for immunoassay techniques, such as FC.
See all LRIG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1954
Antibody Isotype
IgG2b
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucine rich repeats and immunoglobulin like domains 1
Introduction
Among its related pathways are Induced Pluripotent Stem Cell Differentiation Pathways and Internalization of ErbB1 and Embryonic and Lineage-specific Markers. An important paralog of this gene is LRIG3.
Entrez Gene ID
26018
UniProt ID
Q96JA1
Alternative Names
LIG1; LIG-1; leucine-rich repeats and immunoglobulin-like domains protein 1; leucine-rich repeat protein LRIG1; ortholog of mouse integral membrane glycoprotein LIG-1
Function
Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Biological Process
Hair cycle processIEA:Ensembl
InnervationIEA:Ensembl
Otolith morphogenesisIEA:Ensembl
Sensory perception of soundIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 35-794
Helical: 795-815
Cytoplasmic: 816-1093

Moon, J. S., Ho, C. C., Park, J. H., Park, K., Shin, B. Y., Lee, S. H., ... & Lee, S. K. (2023). Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis. Nature Communications, 14(1), 5382.

Hopton, R. E., Jahahn, N. J., & Zemper, A. E. (2023). Lrig1 drives cryptogenesis and restrains proliferation during colon development. American Journal of Physiology-Gastrointestinal and Liver Physiology, 325(6), G570-G581.

Ji, Y., Kumar, R., Gokhale, A., Chao, H. P., Rycaj, K., Chen, X., ... & Tang, D. G. (2022, July). LRIG1, a regulator of stem cell quiescence and a pleiotropic feedback tumor suppressor. In Seminars in cancer biology (Vol. 82, pp. 120-133). Academic Press.

Umeh-Garcia, M., O’Geen, H., Simion, C., Gephart, M. H., Segal, D. J., & Sweeney, C. A. (2022). Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer. British journal of cancer, 127(3), 436-448.

Billing, O., Holmgren, Y., Nosek, D., Hedman, H., & Hemmingsson, O. (2021). LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance. Oncogene, 40(21), 3707-3718.

Marqués-Torrejón, M. Á., Williams, C. A., Southgate, B., Alfazema, N., Clements, M. P., Garcia-Diaz, C., ... & Pollard, S. M. (2021). LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells. Nature communications, 12(1), 2594.

Bakherad, M., Salimi, M., Angaji, S. A., Mahjoubi, F., & Majidizadeh, T. (2021). LRIG1 expression and colorectal cancer prognosis. BMC Medical Genomics, 14, 1-6.

Gao, Y., Liu, C., Zhao, X., Liu, C., Bi, W., & Jia, J. (2021). hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma. Annals of Translational Medicine, 9(15).

Li, W., & Zhou, Y. (2019). LRIG1 acts as a critical regulator of melanoma cell invasion, migration, and vasculogenic mimicry upon hypoxia by regulating EGFR/ERK-triggered epithelial–mesenchymal transition. Bioscience Reports, 39(1), BSR20181165.

Li, Q., Liu, B., Chao, H. P., Ji, Y., Lu, Y., Mehmood, R., ... & Tang, D. G. (2019). LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer. Nature communications, 10(1), 5494.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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