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Rabbit Anti-LIPE Recombinant Antibody (CBFYH-3610) (CBMAB-H4166-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBFYH-3610
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
lipase E, hormone sensitive type
Introduction
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons.
Entrez Gene ID
Human3991
Mouse16890
UniProt ID
HumanQ05469
MouseP54310
Alternative Names
HSL; LHS; AOMS4; FPLD6
Function
Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:8812477, PubMed:15955102, PubMed:15716583, PubMed:19800417).
Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed:19800417).
Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity).
Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity).
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity).
Biological Process
Cholesterol metabolic processIEA:UniProtKB-KW
Diacylglycerol catabolic processISS:UniProtKB
Ether lipid metabolic processISS:UniProtKB
Lipid catabolic processISS:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Triglyceride catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Membrane, caveola
Cytoplasm, cytosol
Lipid droplet
Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959).
Phosphorylation by AMPK reduces its translocation towards the lipid droplets (By similarity).
Involvement in disease
Lipodystrophy, familial partial, 6 (FPLD6):
A form of lipodystrophy characterized by abnormal subcutaneous fat distribution. Affected individuals have increased visceral fat, impaired lipolysis, dyslipidemia, hepatic steatosis, systemic insulin resistance, and diabetes. Some patients manifest muscular dystrophy.
PTM
Phosphorylation by AMPK reduces its translocation towards the lipid droplets.
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For research use only. Not intended for any clinical use.

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