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Mouse Anti-LIG3 Recombinant Antibody (2F3) (CBMAB-0696-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F3
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant 12.8 kDa protein fragment of LIG3
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LIG3
Introduction
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair.
Entrez Gene ID
3980
UniProt ID
P49916
Alternative Names
LIG3; DNA ligase 3; LIG2
Function
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Biological Process
Base-excision repair, DNA ligationManual Assertion Based On ExperimentIDA:BHF-UCL
Base-excision repair, gap-fillingTAS:Reactome
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
DNA biosynthetic processIEA:InterPro
DNA ligationManual Assertion Based On ExperimentIDA:BHF-UCL
Double-strand break repairManual Assertion Based On ExperimentIDA:BHF-UCL
Double-strand break repair via alternative nonhomologous end joiningManual Assertion Based On ExperimentIGI:BHF-UCL
Double-strand break repair via homologous recombinationTAS:Reactome
Lagging strand elongationManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrial DNA repairManual Assertion Based On ExperimentIMP:BHF-UCL
Mitochondrion organizationIDA:BHF-UCL
Negative regulation of mitochondrial DNA replicationManual Assertion Based On ExperimentIMP:CACAO
Cellular Location
Isoform 1&2:
Mitochondrion
Contains an N-terminal mitochondrial transit peptide.
Isoform 3&4:
Nucleus
Lacks the N-terminal mitochondrial transit peptide.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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