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Mouse Anti-Lgals1 Recombinant Antibody (CBYJL-2448) (CBMAB-L2806-YJ)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYJL-2448
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Mouse anti-Rat IgM was raised in Mouse using Rat IgM as the immunogen.
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
0.1% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LGALS1
Introduction
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS1 may act as an autocrine negative growth factor that regulates cell proliferation.Diseases associated with LGALS1 include Benign Metastasizing Leiomyoma and Thyroid Cancer. Among its related pathways are Apoptosis and Autophagy and MAP Kinase Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is LGALS2.
Entrez Gene ID
56646
UniProt ID
P11762
Alternative Names
14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; RL 14.5; S-Lac lectin 1
Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Myoblast differentiationIEA:Ensembl
Plasma cell differentiationIEA:Ensembl
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of viral entry into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
T cell costimulationIEA:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix
Cytoplasm
Secreted
Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
More Infomation

Triguero-Martínez, A., Roy-Vallejo, E., Montes, N., de la Fuente, H., Ortiz, A. M., Castañeda, S., ... & Lamana, A. (2022). Genetic LGALS1 Variants Are Associated with Heterogeneity in Galectin-1 Serum Levels in Patients with Early Arthritis. International Journal of Molecular Sciences, 23(13), 7181.

Sun, H., Zhang, H., Yan, Y., Li, Y., Che, G., Zhou, C., ... & Ma, H. (2022). NCAPG promotes the oncogenesis and progression of non-small cell lung cancer cells through upregulating LGALS1 expression. Molecular cancer, 21(1), 55.

Cai, Z., Yin, K., Liu, Q., Liu, M., Yang, X., & Cui, L. (2022). Association between abnormal expression and methylation of LGALS1 in amyotrophic lateral sclerosis. Brain Research, 1792, 148022.

Ruvolo, P., Ma, H., Ruvolo, V., Zhang, X., Post, S., & Andreeff, M. (2020). AML-044: LGALS1 Acts as a Pro-Survival Molecule in AML. Clinical Lymphoma Myeloma and Leukemia, 20, S176-S177.

Ruvolo, P. P., Ma, H., Ruvolo, V. R., Zhang, X., Post, S. M., & Andreeff, M. (2020). LGALS1 acts as a pro-survival molecule in AML. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1867(10), 118785.

Li, Y., Yang, S., Yue, H., Yuan, D., Li, L., Zhao, J., & Zhao, L. (2020). Unraveling LGALS1 as a potential immune checkpoint and a predictor of the response to anti-PD1 therapy in clear cell renal carcinoma. Pathology & Oncology Research, 26, 1451-1458.

Chen, Q., Han, B., Meng, X., Duan, C., Yang, C., Wu, Z., ... & Cai, J. (2019). Immunogenomic analysis reveals LGALS1 contributes to the immune heterogeneity and immunosuppression in glioma. International journal of cancer, 145(2), 517-530.

Li, J. M., Tseng, C. W., Lin, C. C., Law, C. H., Chien, Y. A., Kuo, W. H., ... & Chan, H. L. (2018). Upregulation of LGALS1 is associated with oral cancer metastasis. Therapeutic Advances in Medical Oncology, 10, 1758835918794622.

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For research use only. Not intended for any clinical use.

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