Mouse Anti-LCOR Recombinant Antibody (CBYJL-1307) (CBMAB-L0888-YJ)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYJL-1307

Antibody Isotype

IgG2b

Application

ICC, IF

Basic Information

Immunogen

E. coli-derived recombinant human LCoR Asn110-Gln338.

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, 5% trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 110-338

Target

Full Name

LCOR

Introduction

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box. It may act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.

Entrez Gene ID

84458

UniProt ID

Q96JN0

Alternative Names

C10orf12; MLR2

Function

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity).
Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.

Biological Process

Cellular response to estradiol stimulusManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

More Infomation

References

Notaro, U. S., Huber, E., Stassi, A. F., Ormaechea, N. E., Chiaraviglio, J. A., Baravalle, M. E., ... & Salvetti, N. R. (2023). Estrogens receptors, nuclear coactivator 1 and ligand-dependent corepressor expression are altered early during induced ovarian follicular persistence in dairy cattle. Theriogenology, 210, 17-27.

Flindris, S., Katsoulas, N., Goussia, A., Lazaris, A. C., Navrozoglou, I., Paschopoulos, M., & Thymara, I. (2021). The expression of NRIP1 and LCOR in endometrioid endometrial cancer. in vivo, 35(5), 2631-2640.

Vogelsang, T. L., Schmoeckel, E., Kuhn, C., Blankenstein, T., Temelkov, M., Heidegger, H., ... & Vattai, A. (2020). Regulation of LCoR and RIP140 expression in cervical intraepithelial neoplasia and correlation with CIN progression and dedifferentiation. Journal of Cancer Research and Clinical Oncology, 146, 1847-1855.

Sixou, S., Müller, K., Jalaguier, S., Kuhn, C., Harbeck, N., Mayr, D., ... & Cavaillès, V. (2018). Importance of RIP140 and LCoR sub-cellular localization for their association with breast cancer aggressiveness and patient survival. Translational Oncology, 11(5), 1090-1096.

Shalom-Barak, T., Liersemann, J., Memari, B., Flechner, L., Devor, C. E., Bernardo, T. M., ... & Barak, Y. (2018). Ligand-dependent corepressor (LCoR) is a rexinoid-inhibited peroxisome proliferator-activated receptor γ–retinoid X receptor α coactivator. Molecular and cellular biology, 38(9), e00107-17.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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