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Mouse Anti-LAMC1 Antibody (D18) (CBMAB-1382CQ)


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Summary

Host Animal
Mouse
Specificity
Rat, Guinea pig, Human
Clone
D18
Antibody Isotype
IgG2a, κ
Application
IF, IHC, IP, WB

Basic Information

Immunogen
Adult rat glomerular basement membrane
Specificity
Rat, Guinea pig, Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LAMC1
Introduction
This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly.
Entrez Gene ID
Human3915
Guinea pig100734278
Rat117036
UniProt ID
HumanP11047
Guinea pigH0VBS9
RatF1MAA7
Alternative Names
B2e; laminin subunit gamma 1
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Cell adhesionManual Assertion Based On ExperimentIDA:HGNC-UCL
Cell migrationManual Assertion Based On ExperimentIMP:HGNC-UCL
Endoderm developmentManual Assertion Based On ExperimentTAS:ProtInc
Extracellular matrix disassemblyManual Assertion Based On ExperimentIMP:HGNC-UCL
Hemidesmosome assemblyManual Assertion Based On ExperimentIMP:HGNC-UCL
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentTAS:HGNC-UCL
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:HGNC-UCL
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:BHF-UCL
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
More Infomation

Bai, J., Zheng, A., Ha, Y., Xu, X., Yu, Y., Lu, Y., ... & Jie, W. (2022). Comprehensive analysis of LAMC1 expression and prognostic value in kidney renal papillary cell carcinoma and clear cell carcinoma. Frontiers in Molecular Biosciences, 9, 988777.

Wang, Z., Jiao, P., Zhong, Y., Ji, H., Zhang, Y., Song, H., ... & Wu, H. (2022). The endoplasmic reticulum-stressed head and neck squamous cell carcinoma cells induced exosomal miR-424-5p inhibits angiogenesis and migration of humanumbilical vein endothelial cells through LAMC1-mediated Wnt/β-catenin signaling pathway. Cell Transplantation, 31, 09636897221083549.

Fang, Y., Dou, R., Huang, S., Han, L., Fu, H., Yang, C., ... & Xiong, B. (2022). LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis. International Journal of Biological Sciences, 18(7), 3082.

Wang, Y. Q., Huang, G., Chen, J., Cao, H., & Xu, W. T. (2021). LncRNA SNHG6 promotes breast cancer progression and epithelial-mesenchymal transition via miR-543/LAMC1 axis. Breast Cancer Research and Treatment, 188, 1-14.

Fang, L., Che, Y., Zhang, C., Huang, J., Lei, Y., Lu, Z., ... & He, J. (2021). LAMC1 upregulation via TGFβ induces inflammatory cancer‐associated fibroblasts in esophageal squamous cell carcinoma via NF‐κB–CXCL1–STAT3. Molecular oncology, 15(11), 3125-3146.

Zhi-Rong, H. A. N., Jiang, X. L., & Wen-Chuan, F. A. N. (2021). LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies. Neoplasma, 68(4).

Kunitomi, H., Kobayashi, Y., Wu, R. C., Takeda, T., Tominaga, E., Banno, K., & Aoki, D. (2020). LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer. Journal of gynecologic oncology, 31(2).

Liu, J., Liu, D., Yang, Z., & Yang, Z. (2019). High LAMC1 expression in glioma is associated with poor prognosis. OncoTargets and therapy, 12, 4253.

Ye, G., Qin, Y., Wang, S., Pan, D., Xu, S., Wu, C., ... & Shen, H. (2019). Lamc1 promotes the Warburg effect in hepatocellular carcinoma cells by regulating PKM2 expression through AKT pathway. Cancer biology & therapy, 20(5), 711-719.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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