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Mouse Anti-LAMA4 Recombinant Antibody (5G8) (CBMAB-L0542-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5G8
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 25-270 of human LAMA4(NP_001098676) produced in E. coli.ImmunogenType: Recombinant protein.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 25-270

Target

Full Name
laminin subunit alpha 4
Introduction
Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Diseases associated with LAMA4 include Cardiomyopathy, Dilated, 1Jj and Familial Isolated Dilated Cardiomyopathy.
Entrez Gene ID
3910
UniProt ID
Q16363
Alternative Names
LAMA3; CMD1JJ; LAMA4*-1
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Biological Process
Cell adhesionIEA:UniProtKB-KW
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Regulation of cell adhesionIEA:InterPro
Regulation of cell migrationIEA:InterPro
Regulation of embryonic developmentIEA:InterPro
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
Major component.
Involvement in disease
Cardiomyopathy, dilated 1JJ (CMD1JJ):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
More Infomation

Cai, H., Kondo, M., Sandhow, L., Xiao, P., Johansson, A. S., Sasaki, T., ... & Qian, H. (2022). Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression. Blood, The Journal of the American Society of Hematology, 139(20), 3040-3057.

Ren, Y., Yang, X., Luo, Z., Wu, J., & Lin, H. (2022). HIF-1α aggravates pathologic myopia through the miR-150-5p/LAMA4/p38 MAPK signaling axis. Molecular and Cellular Biochemistry, 1-10.

Wang, M., Li, C., Liu, Y., & Wang, Z. (2021). Effect of LAMA4 on prognosis and its correlation with immune infiltration in gastric cancer. BioMed Research International, 2021.

Zheng, B., Qu, J., Ohuchida, K., Feng, H., Chong, S. J. F., Yan, Z., ... & Nakamura, M. (2020). LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer. Theranostics, 10(22), 10274.

Liu, Y., Xu, Y., Ding, L., Yu, L., Zhang, B., & Wei, D. (2020). LncRNA MEG3 suppressed the progression of ovarian cancer via sponging miR-30e-3p and regulating LAMA4 expression. Cancer Cell International, 20(1), 1-15.

Peng, L., Li, Y., Wei, S., Li, X., Dang, Y., Zhang, W., & Zhang, G. (2020). LAMA4 activated by Androgen receptor induces the cisplatin resistance in gastric cancer. Biomedicine & Pharmacotherapy, 124, 109667.

Shkurnikov, M., Nikulin, S., Nersisyan, S., Poloznikov, A., Zaidi, S., Baranova, A., ... & Tonevitsky, A. (2019). LAMA4-regulating miR-4274 and its host gene SORCS2 play a role in IGFBP6-dependent effects on phenotype of basal-like breast cancer. Frontiers in molecular biosciences, 6, 122.

Li, Y., Guan, B., Liu, J., Zhang, Z., He, S., Zhan, Y., ... & Zhao, W. (2019). MicroRNA-200b is downregulated and suppresses metastasis by targeting LAMA4 in renal cell carcinoma. EBioMedicine, 44, 439-451.

Yang, Z. X., Zhang, B., Wei, J., Jiang, G. Q., Wu, Y. L., Leng, B. J., & Xing, C. G. (2018). MiR-539 inhibits proliferation and migration of triple-negative breast cancer cells by down-regulating LAMA4 expression. Cancer cell international, 18(1), 1-10.

Wang, X., Hou, Q., & Zhou, X. (2018). LAMA4 expression is activated by zinc finger E‑box‑binding homeobox 1 and independently predicts poor overall survival in gastric cancer. Oncology Reports, 40(3), 1725-1733.

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For research use only. Not intended for any clinical use.

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