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Rabbit Anti-KRT17 Recombinant Antibody (V21-R) (CBMAB-K1675-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
V21-R
Antibody Isotype
IgG
Application
IHC-P, IHC-Fr

Basic Information

Immunogen
Peptide derived from C-terminal region of human cytokeratin 17
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
keratin 17
Introduction
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
Entrez Gene ID
3872
UniProt ID
Q04695
Alternative Names
Keratin 17; Keratin 17; Type I; Cytokeratin-17; CK-17; 39.1; K17;
Function
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity).
Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity).
Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity).
Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity).
May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Biological Process
Hair follicle morphogenesisISS:UniProtKB
Intermediate filament organizationIEA:Ensembl
KeratinizationIEA:Ensembl
Positive regulation of cell growthIEA:Ensembl
Positive regulation of hair follicle developmentIEA:Ensembl
Positive regulation of translationIEA:Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Pachyonychia congenita 2 (PC2):
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
Steatocystoma multiplex (SM):
Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
PTM
Phosphorylation at Ser-44 oCcurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.
More Infomation

Zhang, H., Zhang, Y., Feng, Z., Lu, L., Li, Y., Liu, Y., & Chen, Y. (2022). Analysis of the Expression and Role of Keratin 17 in Human Tumors. Frontiers in Genetics, 13, 801698.

Li, M., Rao, X., Cui, Y., Zhang, L., Li, X., Wang, B., ... & Zhuo, W. (2022). The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer. Oncogene, 41(6), 770-781.

Li, C., Teng, Y., Wu, J., Yan, F., Deng, R., Zhu, Y., & Li, X. (2021). A pan-cancer analysis of the oncogenic role of Keratin 17 (KRT17) in human tumors. Translational cancer research, 10(10), 4489.

Ji, R., Ji, Y., Ma, L., Ge, S., Chen, J., Wu, S., ... & Liu, Z. (2021). Keratin 17 upregulation promotes cell metastasis and angiogenesis in colon adenocarcinoma. Bioengineered, 12(2), 12598-12611.

Jacob, J. T., Nair, R. R., Poll, B. G., Pineda, C. M., Hobbs, R. P., Matunis, M. J., & Coulombe, P. A. (2020). Keratin 17 regulates nuclear morphology and chromatin organization. Journal of cell science, 133(20), jcs254094.

Liu, Z., Yu, S., Ye, S., Shen, Z., Gao, L., Han, Z., ... & Kang, M. (2020). Keratin 17 activates AKT signalling and induces epithelial-mesenchymal transition in oesophageal squamous cell carcinoma. Journal of proteomics, 211, 103557.

Yang, L., Zhang, S., & Wang, G. (2019). Keratin 17 in disease pathogenesis: from cancer to dermatoses. The Journal of pathology, 247(2), 158-165.

Liu, J., Liu, L., Cao, L., & Wen, Q. (2018). Keratin 17 promotes lung adenocarcinoma progression by enhancing cell proliferation and invasion. Medical science monitor: international medical journal of experimental and clinical research, 24, 4782.

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For research use only. Not intended for any clinical use.

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