KRT17
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.
Full Name
keratin 17
Function
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity).
Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity).
Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity).
Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity).
May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity).
Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity).
Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity).
May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Biological Process
Hair follicle morphogenesisISS:UniProtKB
Intermediate filament organizationIEA:Ensembl
KeratinizationIEA:Ensembl
Positive regulation of cell growthIEA:Ensembl
Positive regulation of hair follicle developmentIEA:Ensembl
Positive regulation of translationIEA:Ensembl
Intermediate filament organizationIEA:Ensembl
KeratinizationIEA:Ensembl
Positive regulation of cell growthIEA:Ensembl
Positive regulation of hair follicle developmentIEA:Ensembl
Positive regulation of translationIEA:Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Pachyonychia congenita 2 (PC2):
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
Steatocystoma multiplex (SM):
Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
Steatocystoma multiplex (SM):
Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
PTM
Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.
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Anti-KRT17 antibodies
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CompareTarget: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A799
Application*: FC, ICC, IF, IHC, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A798
Application*: IF, IHC, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A797
Application*: ELISA, IP, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A796
Application*: ICC, IHC, IP, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: A795
Application*: ICC, IHC, IP, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CAP920
Application*: ICC, IHC, WB
Target: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP919
Application*: FC, ICC, IF, IHC, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: PT0082
Application*: IHC
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5C1
Application*: IHC
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP918
Application*: IHC, IP, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB119A
Application*: ELISA, IHC
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB16A
Application*: ELISA, WB, IP
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB297
Application*: WB, IP
Target: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb147
Application*: WB, IH, IF
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBCNC-630
Application*: WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-629
Application*: WB, IP
Target: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-4002
Application*: WB, IP, P, IC
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat, Goat, Cattle, Human, Pig
Clone: CBWJC-3999
Application*: WB, C, DB, IC
Target: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-2280
Application*: WB, P, F, IC
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-2279
Application*: WB, F, E, IC
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3B12
Application*: WB, IH, E
Target: KRT17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0666
Application*: E, P, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0665
Application*: E, IF, P, IP, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-3126
Application*: WB, E, IF
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P096
Application*: WB, IC, P, C, E
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: CBYY-C2825
Application*: F, IC, IH, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2824
Application*: IH, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: 4A32
Application*: F, IC, C, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2K5
Application*: WB, IP
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: Ks17-E3
Application*: C, P, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat, Cattle, Goat, Pig
Clone: KRT17/778
Application*: P, IF/IC, F
Target: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D4G2
Application*: WB, P, IF
Target: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D32D9
Application*: WB, P
Target: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D12E5
Application*: WB, IF, F
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: 83-13
Application*: WB
Target: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V21-R
Application*: P, C
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Rat, Human, Cattle, Goat, Pig
Clone: SPM560
Application*: WB, C, IF/IC, F
Target: KRT17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP95
Application*: P
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CTKN17-1
Application*: IF, P
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AT9F3
Application*: IA, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 3H2058
Application*: IH, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3B12
Application*: E, IA, P, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: 2Q1090
Application*: IH, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D10
Application*: E, WB, IH
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 13B180
Application*: E, IH, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10A1
Application*: IP, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Rat
Clone: E3
Application*: IF, P
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 12B1
Application*: WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D4-1G9
Application*: E, IC, IF, P, IP, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat, Pig, Cattle, Goat
Clone: Ks17.E3
Application*: E, F, IC, IF, C, P, IP, WB
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT21
Application*: WB, P, IF, IC, IP
Target: KRT17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT421
Application*: WB, P, IF, E
Target: KRT17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3106
Application*: WB, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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