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Mouse Anti-KLF7 Monoclonal Antibody (AT3G3) (CBMAB-1371-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
AT3G3
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant full length protein corresponding to Human KLF7 aa 1-302. purified from E. coli (NP_003700)
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Kruppel like factor 7
Introduction
KLF7 is a member of the Kruppel-like transcriptional regulator family. KLF7 may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes.
Entrez Gene ID
Human8609
Mouse93691
UniProt ID
HumanO75840
MouseQ99JB0
Alternative Names
UKLF
Function
Transcriptional factor (PubMed:9774444, PubMed:16339272).
Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity).
Represses the corneal epithelium differentiation (PubMed:28916725).
Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272).
Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).
Biological Process
Axon guidanceISS:UniProtKB
AxonogenesisISS:UniProtKB
Dendrite morphogenesisISS:UniProtKB
Glucose homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of adipose tissue developmentManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin secretion involved in cellular response to glucose stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of epidermal cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
More Infomation

Mao, Y., Chen, Y., & Zhang, Z. (2023). Molecular function of Krüppel-like factor 7 in biology: Molecular function of KLF7 in biology. Acta Biochimica et Biophysica Sinica, 55(5), 713.

Chen, C., Hu, F., Miao, S., Sun, L., Jiao, Y., Xu, M., ... & Zhou, R. (2022). Transcription factor KLF7 promotes osteoclast differentiation by suppressing HO-1. Frontiers in Genetics, 13, 798433.

Lyu, J., Wang, J., Miao, Y., Xu, T., Zhao, W., Bao, T., & Zhu, H. (2022). KLF7 is associated with poor prognosis and regulates migration and adhesion in tongue cancer. Oral Diseases, 28(3), 577-584.

Huang, W. H., Xue, Y. J., Zhou, Y. J., Wu, X. G., Wu, X. X., Zhang, X. X., ... & Wei, Y. T. (2020). KLF7 promotes macrophage activation by activating the NF-κB signaling pathway in epicardial adipose tissue in patients with coronary artery disease. European Review for Medical & Pharmacological Sciences, 24(12).

Niu, R., Tang, Y., Xi, Y., & Jiang, D. (2020). High expression of Krüppel-like factor 7 indicates unfavorable clinical outcomes in patients with lung adenocarcinoma. Journal of Surgical Research, 250, 216-223.

Yang, J., Xie, K., Wang, Z., & Li, C. (2020). Elevated KLF7 levels may serve as a prognostic signature and might contribute to progression of squamous carcinoma. FEBS Open Bio, 10(8), 1577-1586.

Gupta, R., Malvi, P., Parajuli, K. R., Janostiak, R., Bugide, S., Cai, G., ... & Wajapeyee, N. (2020). KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity. Proceedings of the National Academy of Sciences, 117(22), 12341-12351.

Guan, F., Kang, Z., Zhang, J. T., Xue, N. N., Yin, H., Wang, L., ... & Hu, Z. Q. (2019). KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL. Biochemical and biophysical research communications, 514(1), 51-57.

Zhang, M., Wang, C., Wu, J., Ha, X., Deng, Y., Zhang, X., ... & Zhang, J. (2018). The effect and mechanism of KLF7 in the TLR4/NF-κB/IL-6 inflammatory signal pathway of adipocytes. Mediators of Inflammation, 2018.

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For research use only. Not intended for any clinical use.

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