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Mouse Anti-KLF7 Recombinant Antibody (CBLY1-110) (CBMAB-K1123-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLY1-110
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kruppel like factor 7
Introduction
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Entrez Gene ID
8609
UniProt ID
O75840
Alternative Names
Kruppel Like Factor 7; Kruppel-Like Factor 7 (Ubiquitous); Ubiquitous Kruppel-Like Factor; UKLF; Ubiquitous Kruppel-Like Transcription Factor; Ubiquitous Krueppel-Like Factor; Krueppel-Like Factor 7;
Function
Transcriptional factor (PubMed:9774444, PubMed:16339272).
Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity).
Represses the corneal epithelium differentiation (PubMed:28916725).
Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272).
Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).
Biological Process
Axon guidanceISS:UniProtKB
AxonogenesisISS:UniProtKB
Dendrite morphogenesisISS:UniProtKB
Glucose homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of adipose tissue developmentManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin secretion involved in cellular response to glucose stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of epidermal cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
More Infomation

Mao, Y., Chen, Y., & Zhang, Z. (2023). Molecular function of Krüppel-like factor 7 in biology: Molecular function of KLF7 in biology. Acta Biochimica et Biophysica Sinica, 55(5), 713.

Chen, C., Hu, F., Miao, S., Sun, L., Jiao, Y., Xu, M., ... & Zhou, R. (2022). Transcription factor KLF7 promotes osteoclast differentiation by suppressing HO-1. Frontiers in Genetics, 13, 798433.

Lyu, J., Wang, J., Miao, Y., Xu, T., Zhao, W., Bao, T., & Zhu, H. (2022). KLF7 is associated with poor prognosis and regulates migration and adhesion in tongue cancer. Oral Diseases, 28(3), 577-584.

Huang, W. H., Xue, Y. J., Zhou, Y. J., Wu, X. G., Wu, X. X., Zhang, X. X., ... & Wei, Y. T. (2020). KLF7 promotes macrophage activation by activating the NF-κB signaling pathway in epicardial adipose tissue in patients with coronary artery disease. European Review for Medical & Pharmacological Sciences, 24(12).

Niu, R., Tang, Y., Xi, Y., & Jiang, D. (2020). High expression of Krüppel-like factor 7 indicates unfavorable clinical outcomes in patients with lung adenocarcinoma. Journal of Surgical Research, 250, 216-223.

Yang, J., Xie, K., Wang, Z., & Li, C. (2020). Elevated KLF7 levels may serve as a prognostic signature and might contribute to progression of squamous carcinoma. FEBS Open Bio, 10(8), 1577-1586.

Gupta, R., Malvi, P., Parajuli, K. R., Janostiak, R., Bugide, S., Cai, G., ... & Wajapeyee, N. (2020). KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity. Proceedings of the National Academy of Sciences, 117(22), 12341-12351.

Guan, F., Kang, Z., Zhang, J. T., Xue, N. N., Yin, H., Wang, L., ... & Hu, Z. Q. (2019). KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL. Biochemical and biophysical research communications, 514(1), 51-57.

Zhang, M., Wang, C., Wu, J., Ha, X., Deng, Y., Zhang, X., ... & Zhang, J. (2018). The effect and mechanism of KLF7 in the TLR4/NF-κB/IL-6 inflammatory signal pathway of adipocytes. Mediators of Inflammation, 2018.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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