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Mouse Anti-KIR2DS4 Recombinant Antibody (MM0442-2G42) (CBMAB-K0109-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
MM0442-2G42
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human KIR2DS4
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 4
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3809
UniProt ID
P43632
Alternative Names
Killer Cell Immunoglobulin Like Receptor; Two Ig Domains And Short Cytoplasmic Tail 4; Killer Cell Immunoglobulin-Like Receptor; Two Domains; Short Cytoplasmic Tail; 4; P58 Natural Killer Cell Receptor Clones CL-39/CL-17; Natural Killer-Associated Transcript 8; CD158 Antigen-Like Family Member I; P58 NK Receptor CL-39/CL-17; CD158I; NKAT-8; NKAT8; KKA3;
Function
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
Cellular Location
Cell membrane
Topology
Extracellular: 22-245
Helical: 246-265
Cytoplasmic: 266-304
More Infomation

Gowdavally, S., Tsamadou, C., Platzbecker, U., Sala, E., Valerius, T., Klein, S., ... & Fuerst, D. (2023). KIR2DS4 and Its Variant KIR1D in KIR-AA Genotype Donors Showed Differential Survival Impact in Patients with Lymphoid Disease after HLA-Matched Unrelated Hematopoietic Stem Cell Transplantation. Transplantation and Cellular Therapy.

Barani, S., Taghipour, M., & Ghaderi, A. (2020). Positive association of Bx genotype, KIR2L5, KIR2DS5 and full-length KIR2DS4 with the risk of meningioma. Immunobiology, 225(2), 151900.

Barani, S., Khademi, B., & Ghaderi, A. (2020). KIR2DS4, KIR2DL2, and KIR2DS4del are linked with basaloid tumors, lymph node metastasis, advanced stage and metastatic risk in head and neck squamous cell carcinoma. Experimental and Molecular Pathology, 112, 104345.

An, K., Li, B., Luo, C., Wang, J., Luo, C., & Chen, J. (2020). The impact of donor full‐length KIR2DS4 in the development of acute and chronic GVHD after unrelated allogeneic HSCT. Pediatric Transplantation, 24(6), e13728.

Sim, M. J., Rajagopalan, S., Altmann, D. M., Boyton, R. J., Sun, P. D., & Long, E. O. (2019). Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C. Proceedings of the National Academy of Sciences, 116(26), 12964-12973.

Schenk, A., Pulverer, W., Koliamitra, C., Bauer, C. J., Ilic, S., Heer, R., ... & Zimmer, P. (2019). Acute exercise increases the expression of KIR2DS4 by promoter demethylation in NK cells. International journal of sports medicine, 40(01), 62-70.

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For research use only. Not intended for any clinical use.

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