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Mouse Anti-ITFG2 Recombinant Antibody (CBYY-I2013) (CBMAB-I3183-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Monkey
Clone
CBYY-I2013
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human ITFG2(NP_060933)
Specificity
Human, Rat, Monkey
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.84 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Integrin Alpha FG-GAP Repeat Containing 2
Introduction
ITFG2 (Integrin Alpha FG-GAP Repeat Containing 2) is a Protein Coding gene.
Entrez Gene ID
Human55846
Monkey708596
Rat362441
UniProt ID
HumanQ969R8
MonkeyG7PJK5
RatD4A716
Alternative Names
Integrin Alpha FG-GAP Repeat Containing 2
Function
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Biological Process
Cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Germinal center B cell differentiationIEA:Ensembl
Negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of TOR signalingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Lysosome membrane. Localization to lysosomes is amino acid-independent.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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