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Mouse Anti-ITFG2 Recombinant Antibody (2E8) (CBMAB-A5363-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E8
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MDS028 (AAH06552, 1 a.a. ~ 447 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Integrin Alpha FG-GAP Repeat Containing 2
Entrez Gene ID
55846
UniProt ID
Q969R8
Alternative Names
MDS028
Function
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Biological Process
Cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Germinal center B cell differentiationIEA:Ensembl
Negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of TOR signalingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Lysosome membrane. Localization to lysosomes is amino acid-independent.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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