Mouse Anti-INSRR Recombinant Antibody (CBYY-I1192) (CBMAB-I2361-YY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-I1192

Antibody Isotype

IgG1, κ

Application

ELISA, IHC-P, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Concentration

0.5 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

insulin receptor-related receptor

Introduction

INSRR (Insulin Receptor Related Receptor) is a Protein Coding gene. Diseases associated with INSRR include Regular Astigmatism and Podoconiosis. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex.

Entrez Gene ID

3645

UniProt ID

P14616

Alternative Names

Insulin Receptor Related Receptor

Function

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to alkaline pHManual Assertion Based On ExperimentIDA:UniProtKB
Male sex determinationIEA:Ensembl
Positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 747-921
Helical: 922-943
Cytoplasmic: 944-1297

PTM

Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.

More Infomation

References

Zhang, H., Bao, M., Liao, D., Zhang, Z., Tian, Z., Yang, E., ... & Jiang, X. (2023). Identification of INSRR as an immune-related gene in the tumor microenvironment of glioblastoma by integrated bioinformatics analysis. Medical Oncology, 40(6), 161.

Gantsova, E. A., Deyev, I. E., Petrenko, A. G., & Serova, O. V. (2022). Analysis of the Development of Insrr Knockout Mouse Preimplantation Embryos. Russian Journal of Developmental Biology, 53(3), 192-197.

Gantsova, E. A., Gavrilenkova, A. A., Serova, O. V., & Deyev, I. E. (2022, August). Changes in the Expression of the gapdh Gene in the Organs of insrr Knockout Mice. In Doklady Biological Sciences (Vol. 505, No. 1, pp. 113-118). Moscow: Pleiades Publishing.

Deyev, I. E., Shayahmetova, D. M., Zhenilo, S. V., Radionov, N. V., & Petrenko, A. G. (2018). Profile of Gene Expression in the Kidneys of Mice with the insrr Gene Knockout. Russian Journal of Bioorganic Chemistry, 44, 256-260.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

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Mouse Anti-INSRR Recombinant Antibody (CBYY-I1012)

Mouse Anti-INSRR Recombinant Antibody (5C6)

Rabbit Anti-INSRR Recombinant Antibody (CBYY-I0764)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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