Mouse Anti-INSRR Recombinant Antibody (2C1) (CBMAB-A4495-LY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Rat

Clone

2C1

Antibody Isotype

IgG1, κ

Application

WB, ELISA

Basic Information

Immunogen

INSRR (NP_055030, 651 a.a. ~ 760 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

insulin receptor-related receptor

Entrez Gene ID

Human	3645
Rat	60663

UniProt ID

Human	P14616
Rat	Q64716

Alternative Names

IRR

Function

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to alkaline pHManual Assertion Based On ExperimentIDA:UniProtKB
Male sex determinationIEA:Ensembl
Positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 747-921
Helical: 922-943
Cytoplasmic: 944-1297

PTM

Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.

More Infomation

References

Zhang, H., Bao, M., Liao, D., Zhang, Z., Tian, Z., Yang, E., ... & Jiang, X. (2023). Identification of INSRR as an immune-related gene in the tumor microenvironment of glioblastoma by integrated bioinformatics analysis. Medical Oncology, 40(6), 161.

Gantsova, E. A., Deyev, I. E., Petrenko, A. G., & Serova, O. V. (2022). Analysis of the Development of Insrr Knockout Mouse Preimplantation Embryos. Russian Journal of Developmental Biology, 53(3), 192-197.

Gantsova, E. A., Gavrilenkova, A. A., Serova, O. V., & Deyev, I. E. (2022, August). Changes in the Expression of the gapdh Gene in the Organs of insrr Knockout Mice. In Doklady Biological Sciences (Vol. 505, No. 1, pp. 113-118). Moscow: Pleiades Publishing.

Deyev, I. E., Shayahmetova, D. M., Zhenilo, S. V., Radionov, N. V., & Petrenko, A. G. (2018). Profile of Gene Expression in the Kidneys of Mice with the insrr Gene Knockout. Russian Journal of Bioorganic Chemistry, 44, 256-260.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Rabbit Anti-INSRR Recombinant Antibody (CBYY-I0764)

Mouse Anti-INSRR Recombinant Antibody (5C6)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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