Mouse Anti-INA Recombinant Antibody (CBYY-I0245) (CBMAB-I0642-YY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-I0245

Antibody Isotype

IgG1

Application

IF, IHC-P, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

internexin neuronal intermediate filament protein alpha

Introduction

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons.

Entrez Gene ID

9118

UniProt ID

Q16352

Alternative Names

Internexin Neuronal Intermediate Filament Protein Alpha

Function

Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity).

Biological Process

Cell differentiationIEA:UniProtKB-KW
Cellular response to leukemia inhibitory factorIEA:Ensembl
Neurofilament cytoskeleton organizationIEA:Ensembl
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Cytoplasmic ribonucleoprotein granule; Extracellular space; Neurofilament; Postsynapse; Schaffer collateral - CA1 synapse

PTM

O-glycosylated.

More Infomation

References

Murakami, A., Nakamura, M., Nakamura, Y., Kaneko, S., Yakushiji, Y., & Kusaka, H. (2021). An autopsy case report of neuronal intermediate filament inclusion disease presenting with predominantly upper motor neuron features. Neuropathology, 41(5), 357-365.

Li, Y., Bai, L., Yu, H., Cai, D., Wang, X., Huang, B., ... & Luo, Y. (2020). Epigenetic inactivation of α-internexin accelerates microtubule polymerization in colorectal cancer. Cancer Research, 80(23), 5203-5215.

Rajmohan, K. S., Sugur, H. S., Shwetha, S. D., Pandey, P., Arivazhagan, A., & Santosh, V. (2020). Alpha internexin: a surrogate marker for 1p/19q codeletion and prognostic marker in anaplastic (WHO grade III) gliomas. Neurology India, 68(4), 832.

Hawley, Z. C., Campos-Melo, D., & Strong, M. J. (2019). MiR-105 and miR-9 regulate the mRNA stability of neuronal intermediate filaments. Implications for the pathogenesis of amyotrophic lateral sclerosis (ALS). Brain Research, 1706, 93-100.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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