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Mouse Anti-IFNB1 Recombinant Antibody (AG92) (V2LY-0524-LY64)


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Summary

Host Animal
Mouse
Specificity
Mouse
Clone
AG92
Antibody Isotype
IgG2a
Application
Blocking, Neutralization, WB

Basic Information

Immunogen
Plasmid DNA encoding murine IFNb
Host Species
Mouse
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin
< 1.0 EU/mg as determined by the LAL method
Format
Liquid
Buffer
PBS
Preservative
None
Concentration
5 mg/ml
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interferon Beta 1
Entrez Gene ID
15977
UniProt ID
P01575
Alternative Names
Interferon Beta 1
Function
Has antiviral, antibacterial and anticancer activities.
Biological Process
Adaptive immune response Source: GO_Central
B cell activation involved in immune response Source: UniProtKB
B cell differentiation Source: GO_Central
B cell proliferation Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to exogenous dsRNA Source: BHF-UCL
Cellular response to interferon-beta Source: BHF-UCL
Cellular response to virus Source: ARUK-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: BHF-UCL
Humoral immune response Source: GO_Central
Natural killer cell activation Source: UniProtKB
Natural killer cell activation involved in immune response Source: GO_Central
Negative regulation of T cell differentiation Source: UniProtKB
Negative regulation of T-helper 2 cell cytokine production Source: UniProtKB
Negative regulation of viral genome replication Source: BHF-UCL
Positive regulation of apoptotic signaling pathway Source: UniProtKB
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of MHC class I biosynthetic process Source: UniProtKB
Response to exogenous dsRNA Source: MGI
Response to virus Source: UniProtKB
T cell activation involved in immune response Source: GO_Central
Type I interferon signaling pathway Source: BHF-UCL
Cellular Location
Secreted
More Infomation

Schwanke, H., Gonçalves Magalhães, V., Schmelz, S., Wyler, E., Hennig, T., Günther, T., ... & Brinkmann, M. M. (2023). The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes. Journal of Virology, e00400-23.

Zhang, Y., Huang, H., Chen, H., Zhang, P., Liu, Y., Gan, Y., ... & Ren, H. (2023). Unearths IFNB1 immune infiltrates in SOP-related ossification of ligamentum flavum pathogenesis. Heliyon.

Schwanke, H., Goncalves Magalhaes, V., Schmelz, S., Wyler, E., Hennig, T., Guenther, T., ... & Brinkmann, M. M. (2023). The Cytomegalovirus M35 Protein Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes by Direct Promoter Binding. bioRxiv, 2023-03.

Thomsen, E. A., Andersen, S., Marqvorsen, M. H. S., Skipper, K. A., Paludan, S. R., & Mikkelsen, J. G. (2022). Single-Cell Monitoring of Activated Innate Immune Signaling by a d2eGFP-Based Reporter Mimicking Time-Restricted Activation of IFNB1 Expression. Frontiers in Cellular and Infection Microbiology, 11, 784762.

Schwanke, H., Stempel, M., & Brinkmann, M. M. (2020). Of keeping and tipping the balance: host regulation and viral modulation of IRF3-dependent IFNB1 expression. Viruses, 12(7), 733.

Cho, E., Islam, S. B. U., Jiang, F., Park, J. E., Lee, B., Kim, N. D., & Hwang, T. H. (2020). Characterization of oncolytic vaccinia virus harboring the human IFNB1 and CES2 transgenes. Cancer Research and Treatment: Official Journal of Korean Cancer Association, 52(1), 309-319.

Nikopoulou, C., Panagopoulos, G., Sianidis, G., Psarra, E., Ford, E., & Thanos, D. (2019). The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression. Molecular Cell, 74(2), 409-410.

Nikopoulou, C., Panagopoulos, G., Sianidis, G., Psarra, E., Ford, E., & Thanos, D. (2018). The transcription factor ThPOK orchestrates stochastic interchromosomal interactions required for IFNB1 virus-inducible gene expression. Molecular cell, 71(2), 352-361.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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