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Mouse Anti-HSH2D (AA 251-352) Recombinant Antibody (CBFYH-2076) (CBMAB-H3086-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2076
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: SQDHSGDPTS GDRGYTDPCV ATSLKSPSQP QAPKDRKVPT RKAERSVSCI EVTPGDRSWH QMVVRALSSQ ESKPEHQGLA EPENDQLPEE YQQPPPFAPG YC
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 251-352

Target

Full Name
HSH2D
Introduction
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).
Entrez Gene ID
84941
UniProt ID
Q96JZ2
Alternative Names
Hematopoietic SH2 Domain Containing; Adaptor In Lymphocytes Of Unknown Function X; ALX; Hematopoietic SH2 Domain-Containing Protein; Hematopoietic SH2 Protein; HSH2
Function
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity).

Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.
Biological Process
Negative regulation of B cell apoptotic process Source: Ensembl
Negative regulation of mitochondrial depolarization Source: Ensembl
Signal transduction Source: InterPro
T cell activation Source: Ensembl
Cellular Location
Cytoplasm; Nucleus
PTM
May be phosphorylated by FES and ACK1.
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For research use only. Not intended for any clinical use.

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