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Mouse Anti-HSH2D Recombinant Antibody (6G7) (CBMAB-0618-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
6G7
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein SH2 domain of HSH2D (aa. 9-153)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HSH2D
Introduction
The protein has a molecular weight of 39.0 kilodaltons (kD) and a pI of 6.678. The main feature of the protein is the SH2 (Src homology) domain, which is a region that has phosphotyrosine receptors and is important in many signaling molecules. This protein may be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). This is an adapter protein involved in tyrosine kinase and CD28 signaling, which seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.
Entrez Gene ID
84941
UniProt ID
Q96JZ2
Alternative Names
ALX; HSH2
Function
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity).

Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.
Biological Process
Negative regulation of B cell apoptotic process Source: Ensembl
Negative regulation of mitochondrial depolarization Source: Ensembl
Signal transduction Source: InterPro
T cell activation Source: Ensembl
Cellular Location
Cytoplasm; Nucleus
PTM
May be phosphorylated by FES and ACK1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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