Mouse Anti-HOXB6 Antibody (1A4) (CBMAB-0501-YC)

See all HOXB6 antibodies

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1A4

Antibody Isotype

IgG2b

Application

IP, MA

Basic Information

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

HOXB6

Introduction

HOXB6 (homeobox B6) functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. HOXB6 is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. Abnormal expression of HOXB6 is associated with some cases of acute myeloid leukemia and colorectal cancer.

Entrez Gene ID

3216

UniProt ID

P17509

Alternative Names

HOX2; HOX2B

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system morphogenesis Source: Ensembl
Erythrocyte homeostasis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

More Infomation

References

Huang, H., Lu, D., Li, K., Zheng, M., Qin, X., Cui, X., ... & Zhu, B. (2023). Hsa_circ_0007031 promotes the proliferation and migration of osteosarcoma cells by sponging miR-196a-5p to regulate the HOXB6. Biochemical Pharmacology, 115667.

Rittgers, A. L., Le Pabic, P., & Davis, A. (2021). Zebrafish (Danio rerio) Hoxb6: An Exploration into the Divergence of Genomic DNA Sequence and Gene Expression Across Teleost Fishes Post-Genome Duplication. Georgia Journal of Science, 79(2), 2.

Yan, Y., Wang, R., Hu, X., Wang, S., Zhang, L., Hou, C., & Zhang, L. (2020). MiR-126 regulates properties of SOX9+ liver progenitor cells during liver repair by targeting Hoxb6. Stem Cell Reports, 15(3), 706-720.

Li, Y., & Jiang, A. (2020). ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6. Cancer biology & therapy, 21(7), 647-655.

Roubroeks, J. A., Smith, A. R., Smith, R. G., Pishva, E., Ibrahim, Z., Sattlecker, M., ... & Lunnon, K. (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiology of Aging, 95, 26-45.

Mo, J. S., Park, Y. R., & Chae, S. C. (2019). MicroRNA 196B regulates HOXA5, HOXB6 and GLTP expression levels in colorectal cancer cells. Pathology & Oncology Research, 25, 953-959.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-HOXB6 (AA 1-57) Recombinant Antibody (CBFYH-1771)

Mouse Anti-HOXB6 Recombinant Antibody (8E3)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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