Mouse Anti-HOXB6 (AA 1-57) Recombinant Antibody (CBFYH-1771) (CBMAB-H2780-FY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-1771

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFATSS

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-57

Target

Full Name

HOXB6

Introduction

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.

Entrez Gene ID

3216

UniProt ID

P17509

Alternative Names

Homeobox B6; Homeobox Protein Hox-2.2; Homeobox Protein Hox-2B; Homeobox Protein Hu-2; Homeo Box B6; HOX2B

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system morphogenesis Source: Ensembl
Erythrocyte homeostasis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

More Infomation

References

Huang, H., Lu, D., Li, K., Zheng, M., Qin, X., Cui, X., ... & Zhu, B. (2023). Hsa_circ_0007031 promotes the proliferation and migration of osteosarcoma cells by sponging miR-196a-5p to regulate the HOXB6. Biochemical Pharmacology, 115667.

Rittgers, A. L., Le Pabic, P., & Davis, A. (2021). Zebrafish (Danio rerio) Hoxb6: An Exploration into the Divergence of Genomic DNA Sequence and Gene Expression Across Teleost Fishes Post-Genome Duplication. Georgia Journal of Science, 79(2), 2.

Yan, Y., Wang, R., Hu, X., Wang, S., Zhang, L., Hou, C., & Zhang, L. (2020). MiR-126 regulates properties of SOX9+ liver progenitor cells during liver repair by targeting Hoxb6. Stem Cell Reports, 15(3), 706-720.

Li, Y., & Jiang, A. (2020). ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6. Cancer biology & therapy, 21(7), 647-655.

Roubroeks, J. A., Smith, A. R., Smith, R. G., Pishva, E., Ibrahim, Z., Sattlecker, M., ... & Lunnon, K. (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiology of Aging, 95, 26-45.

Mo, J. S., Park, Y. R., & Chae, S. C. (2019). MicroRNA 196B regulates HOXA5, HOXB6 and GLTP expression levels in colorectal cancer cells. Pathology & Oncology Research, 25, 953-959.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-HOXB6 Recombinant Antibody (8E3)

Mouse Anti-HOXB6 Antibody (1A4)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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