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Mouse Anti-HAUS1 Recombinant Antibody (1E3) (CBMAB-C3551-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E3
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa 179-279 from human CCDC5 (NP_612452) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
HAUS Augmin Like Complex Subunit 1
Introduction
HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Entrez Gene ID
115106
UniProt ID
Q96CS2
Alternative Names
HAUS Augmin Like Complex Subunit 1; Coiled-Coil Domain Containing 5 (Spindle Associated); Coiled-Coil Domain-Containing Protein 5; Enhancer Of Invasion-Cluster; CCDC5; HEI-C; HEIC; HAUS Augmin-Like Complex Subunit 1; HsT1461;
Function
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Biological Process
Cell division Source: UniProtKB-KW
Centrosome cycle Source: UniProtKB
Spindle assembly Source: UniProtKB
Cellular Location
Centrosome; Spindle; Spindle pole; Cytoplasm. Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. Localizes to mitotic spindle microtubules.
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For research use only. Not intended for any clinical use.

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