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Mouse Anti-GORAB Recombinant Antibody (CBLG1-2884) (CBMAB-G4377-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2884
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 35-394 of human GORAB(NP_689494) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Golgin, RAB6 Interacting
Introduction
This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Entrez Gene ID
92344
UniProt ID
Q5T7V8
Alternative Names
Golgin; RAB6 Interacting; N-Terminal Kinase-Like-Binding Protein 1; SCY1-Like 1-Binding Protein 1; RAB6-Interacting Golgin; SCYL1-Binding Protein 1; NTKL-Binding Protein 1; SCYL1-BP1; HNTKL-BP1;
Biological Process
Hair follicle morphogenesis Source: Ensembl
Non-motile cilium assembly Source: GO_Central
Positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: Ensembl
Cellular Location
Cytoplasm; Golgi apparatus
Involvement in disease
Geroderma osteodysplasticum (GO):
A rare autosomal recessive disorder characterized by lax, wrinkled skin, joint laxity and a typical face with a prematurely aged appearance. Skeletal signs include severe osteoporosis leading to frequent fractures, malar and mandibular hypoplasia and a variable degree of growth retardation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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