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Mouse Anti-GORAB (AA 35-394) Recombinant Antibody (CBFYH-0423) (CBMAB-H1294-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat, Monkey, Mouse
Clone
CBFYH-0423
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 35-394 of human GORAB produced in E.coli
Specificity
Human, Dog, Rat, Monkey, Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 35-394

Target

Full Name
Golgin, RAB6 Interacting
Introduction
This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described.
Entrez Gene ID
Human92344
Mouse98376
Rat304923
Dog490349
Monkey702571
UniProt ID
HumanQ5T7V8
MouseQ8BRM2
RatB1H222
DogF1PWN8
MonkeyA0A0D9RGM8
Alternative Names
Golgin, RAB6 Interacting; N-Terminal Kinase-Like-Binding Protein 1; SCY1-Like 1-Binding Protein 1; RAB6-Interacting Golgin; SCYL1-Binding Protein 1; NTKL-Binding Protein 1; SCYL1-BP1; HNTKL-BP1
Biological Process
Hair follicle morphogenesis Source: Ensembl
Non-motile cilium assembly Source: GO_Central
Positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: Ensembl
Cellular Location
Cytoplasm; Golgi apparatus
Involvement in disease
Geroderma osteodysplasticum (GO):
A rare autosomal recessive disorder characterized by lax, wrinkled skin, joint laxity and a typical face with a prematurely aged appearance. Skeletal signs include severe osteoporosis leading to frequent fractures, malar and mandibular hypoplasia and a variable degree of growth retardation.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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