Mouse Anti-GNG2 Recombinant Antibody (11F6) (CBMAB-0578-CN)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

11F6

Antibody Isotype

IgG

Application

ELISA, MA

Basic Information

Immunogen

Recombinant full length protein of GNG2

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

guanine nucleotide binding protein (G protein), gamma 2

Introduction

This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).

Entrez Gene ID

54331

UniProt ID

P59768

Alternative Names

GNG2

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).

Biological Process

Adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
Cellular response to catecholamine stimulus Source: BHF-UCL
Cellular response to prostaglandin E stimulus Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

More Infomation

References

Zhao, A., Li, D., Mao, X., Yang, M., Deng, W., Hu, W., ... & Li, L. (2022). GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling. Cell Death & Disease, 13(3), 260.

Chen, S., Huang, M., & Hu, X. (2021). Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression. Molecular Medicine Reports, 24(3), 1-10.

Guo, X., Zou, X., Zhang, L. B., Peng, J., Liu, R., & Tang, H. J. (2020). Nalbuphine Suppressed Cell Proliferation, Migration, and Epithelial-Mesenchymal Transition of Lung Cancer Cells via Up-Regulating G Protein Subunit Gamma 2. Journal of Biomaterials and Tissue Engineering, 10(9), 1272-1280.

Gan, S., Pan, Y., & Mao, J. (2019). miR-30a-GNG2 and miR-15b-ACSS2 interaction pairs may be potentially crucial for development of abdominal aortic aneurysm by influencing inflammation. DNA and Cell Biology, 38(12), 1540-1556.

Feng, Y., Su, Y., Ma, C., Jing, Z., Yang, X., Zhang, D., ... & Wei, J. (2019). 3′ UTR variants of TNS3, PHLDB1, NTN4, and GNG2 genes are associated with IgA nephropathy risk in Chinese Han population. International immunopharmacology, 71, 295-300.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-GNG2 Recombinant Antibody (CBLG1-1418)

Mouse Anti-GNG2 Recombinant Antibody (CBLG1-1419)

Mouse Anti-GNG2 Recombinant Antibody (CBFYH-0404)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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