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Mouse Anti-GFAP Recombinant Antibody (CBLG1-886) (CBMAB-G2954-LY)


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Summary

Host Animal
Mouse
Specificity
Cattle, Human, Mouse, Rat, Chicken, Monkey, Horse, Pig, Cat
Clone
CBLG1-886
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Recombinant GFAP expressed in bacteria and highly purified. Subsequent boosts were performed with GFAP purified from a Triton X-100 extract of myelin associated material from bovine spinal cord
Specificity
Cattle, Human, Mouse, Rat, Chicken, Monkey, Horse, Pig, Cat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
10mM sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glial Fibrillary Acidic Protein
Introduction
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Entrez Gene ID
Human2670
Mouse14580
Rat24387
Pig396562
Chicken419969
Cat101081938
Cattle281189
Monkey712941
UniProt ID
HumanP14136
MouseP03995
RatP47819
PigF1RR02
ChickenF1NE70
CatM3W443
MonkeyA0A1D5QDR4
CattleQ28115
Alternative Names
Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD;
Function
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Biological Process
Astrocyte development Source: Ensembl
Bergmann glial cell differentiation Source: Ensembl
D-aspartate import across plasma membrane Source: Ensembl
Extracellular matrix organization Source: Ensembl
Gene expression Source: Ensembl
Intermediate filament organization Source: UniProtKB
Intracellular protein transport Source: Ensembl
Long-term synaptic potentiation Source: Ensembl
Negative regulation of neuron projection development Source: Ensembl
Neuron projection regeneration Source: Ensembl
Positive regulation of Schwann cell proliferation Source: Ensembl
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of neurotransmitter uptake Source: Ensembl
Regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Response to wounding Source: Ensembl
Cellular Location
Cytoplasm. Associated with intermediate filaments.
Involvement in disease
Alexander disease (ALXDRD):
A rare disorder of the central nervous system. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death within the first decade. Infants with Alexander disease develop a leukodystrophy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. Histologically, Alexander disease is characterized by Rosenthal fibers, homogeneous eosinophilic inclusions in astrocytes.
PTM
Phosphorylated by PKN1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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