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GFAP

This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Full Name
Glial Fibrillary Acidic Protein
Alternative Names
Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD;
Function
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Biological Process
Astrocyte development Source: Ensembl
Bergmann glial cell differentiation Source: Ensembl
D-aspartate import across plasma membrane Source: Ensembl
Extracellular matrix organization Source: Ensembl
Gene expression Source: Ensembl
Intermediate filament organization Source: UniProtKB
Intracellular protein transport Source: Ensembl
Long-term synaptic potentiation Source: Ensembl
Negative regulation of neuron projection development Source: Ensembl
Neuron projection regeneration Source: Ensembl
Positive regulation of Schwann cell proliferation Source: Ensembl
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of neurotransmitter uptake Source: Ensembl
Regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Response to wounding Source: Ensembl
Cellular Location
Cytoplasm. Associated with intermediate filaments.
Involvement in disease
Alexander disease (ALXDRD):
A rare disorder of the central nervous system. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death within the first decade. Infants with Alexander disease develop a leukodystrophy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. Histologically, Alexander disease is characterized by Rosenthal fibers, homogeneous eosinophilic inclusions in astrocytes.
PTM
Phosphorylated by PKN1.

Anti-GFAP antibodies

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Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Chicken, Human, Mouse, Pig, Rabbit, Rat
Clone: CBFYH-0331
Application*: IF, F, IP, WB, C, P
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Pig, Mouse, Rat, Cattle, Human
Clone: 2A5
Application*: IC, IF, C, P, E, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Chicken, Pig, Rat
Clone: ASTRO6
Application*: IF, IC, P, WB
Target: GFAP
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Cattle, Guinea pig, Human, Mouse, Rat
Clone: 2.2B10
Application*: IF, IH, F, IP, E, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Pig, Mouse, Rat, Horse, Chicken, Cattle, Human
Clone: 5C10
Application*: IC, IF, C, P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBLG1-895
Application*: IC, IF, C, P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: CBLG1-894
Application*: E, IC, C, P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Human
Clone: CBLG1-893
Application*: F
Target: GFAP
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBLG1-892
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-891
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBLG1-890
Application*: F
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-889
Application*: C, P
Target: GFAP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-888
Application*: IF, IH, WB
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-887
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Human, Mouse, Rat, Chicken, Monkey, Horse, Pig, Cat
Clone: CBLG1-886
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Human, Mouse, Rat
Clone: CBLG1-885
Application*: IF, C, P, IP, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-884
Application*: C, P
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-881
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Zebrafish
Clone: ZRF-1
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: UMAB5
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: UMAB129
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SB61a
Application*: E, EC
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SB16a
Application*: E
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Human, Mouse, Rat
Clone: S.880.0
Application*: IF, P, WB
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: RM282
Application*: WB
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: RM246
Application*: IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2726
Application*: E
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBLG1-2725
Application*: E
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2724
Application*: LA
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2723
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2722
Application*: E
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat, Monkey
Clone: CBLG1-2721
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2720
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2719
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2718
Application*: E
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Pig, Rat
Clone: n.n
Application*: IC/IF, IP, P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: GFA-02
Application*: F
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cattle, Rat, Mouse
Clone: GF2.24
Application*: IF, C, P
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GF-05
Application*: C, E, IC/IF, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Pig
Clone: GF-02
Application*: C, IC/IF, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Human, Rat
Clone: GA-8
Application*: IH, WB
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBLG1-2717
Application*: WB
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D1F4Q
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ASTRO/789
Application*: F
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 9i163
Application*: IC, IH, IP, WB
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 9i162
Application*: IC, IH, IP, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 8H3
Application*: E, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: 7i20
Application*: IC, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F2
Application*: C, P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 6A89
Application*: IH
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A6
Application*: E, IC, P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Human, Mouse, Rat
Clone: 5F199
Application*: IF, IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5D7
Application*: IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: 5C8
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B1
Application*: IF, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 542721
Application*: E, IC, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4G8
Application*: IF, P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4D11
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4C10
Application*: IF, P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: 4A11
Application*: IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Pig, Rat
Clone: 2Q64
Application*: IC, IH
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2D8
Application*: IF, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2C4
Application*: IF, IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E11
Application*: IF, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1-D4
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B3
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Chicken, Human, Mouse, Rat
Clone: 15j91
Application*: IC, IH, WB
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 13G32D1F4Q
Application*: IF, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Pig, Cattle, Horse, Human, Mouse, Rat
Clone: 13B823
Application*: IF, IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 131-17719G7-19
Application*: IH
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 11E204
Application*: IC, IH
Target: GFAP
Host: Rat
Antibody Isotype: IgM
Specificity: Human, Mouse, Rat, Zebrafish
Clone: 117C9
Application*: IC, IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Human, Mouse, Rat
Clone: 10K205
Application*: IF, IH, IP, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: CBLG1-073
Application*: IH, R, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-072
Application*: IF, IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Human, Mouse, Rat, Cattle, Chicken, Rabbit
Clone: SPM507
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Human, Mouse, Rat, Cattle, Chicken, Rabbit
Clone: SPM248
Application*: WB
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP78
Application*: P
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: SMI24
Application*: P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: SB61b1
Application*: E, IC
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: SB61b
Application*: C, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: S206A-8
Application*: WB
Target: GFAP
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: REA335
Application*: F
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Guinea pig
Clone: MIG-G2
Application*: P
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GFA12-3
Application*: P, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GF2
Application*: IH
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: GF12.24
Application*: IF, IH
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Human, Mouse, Rat, Cattle, Chicken, Rabbit
Clone: GA5
Application*: E
Target: GFAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBLG1-2716
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Mouse, Rat
Clone: CBLG1-2715
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Pig, Rat
Clone: 3F186
Application*: IF, IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Human, Mouse, Rat
Clone: 2E1.E9
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Cat, Chicken, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Sheep
Clone: 2E1
Application*: IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 273807
Application*: WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Chicken, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Sheep
Clone: CBLG1-2714
Application*: C, P
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Rat, Chicken, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Sheep
Clone: 1B4
Application*: C, IF
Target: GFAP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 183CT3.1.5
Application*: E, IF, IH, WB
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 13A188
Application*: IC, IH
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 13A187
Application*: IH
Target: GFAP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 131-17719
Application*: IC, IF
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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