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Rabbit Anti-GDF15 Recombinant Antibody (D2A3) (CBMAB-CP1534-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
D2A3
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Mic-1 protein.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Growth Differentiation Factor 15
Entrez Gene ID
9518
UniProt ID
Q99988
Function
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435).

Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099).

It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886).

On hepatocytes, inhibits growth hormone signaling (By similarity).
Biological Process
Activation of MAPK activity Source: UniProtKB
BMP signaling pathway Source: GO_Central
Cell-cell signaling Source: ProtInc
Glial cell-derived neurotrophic factor receptor signaling pathway Source: UniProtKB
Negative regulation of growth hormone receptor signaling pathway Source: UniProtKB
Negative regulation of multicellular organism growth Source: UniProtKB
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of myoblast fusion Source: Ensembl
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
Positive regulation of protein kinase B signaling Source: UniProtKB
Reduction of food intake in response to dietary excess Source: UniProtKB
Signal transduction Source: ProtInc
SMAD protein signal transduction Source: UniProtKB
Transforming growth factor beta receptor signaling pathway Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Plasma levels are increased in children with concomitant heart disease and failure to thrive but not in children with heart disease and normal body weight.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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