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Mouse Anti-FSCN1 Recombinant Antibody (V2-162404) (CBMAB-F2482-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-162404
Antibody Isotype
IgG2a
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fascin Actin-Bundling Protein 1
Introduction
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
Entrez Gene ID
6624
UniProt ID
Q16658
Alternative Names
Fascin Actin-Bundling Protein 1; 55 KDa Actin-Bundling Protein; FAN1; P55; SNL; HSN; Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus); Singed (Drosophila)-Like (Sea Urchin Fascin Homolog Like);
Function
Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945).

Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945).

Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786).

Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945).

Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Cell-cell junction assembly Source: UniProtKB
Cell migration Source: UniProtKB
Cell motility Source: UniProtKB
Establishment of apical/basal cell polarity Source: UniProtKB
Establishment or maintenance of cell polarity Source: GO_Central
Microspike assembly Source: UniProtKB
Parallel actin filament bundle assembly Source: UniProtKB
Positive regulation of extracellular matrix disassembly Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of lamellipodium assembly Source: UniProtKB
Positive regulation of podosome assembly Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of microvillus assembly Source: UniProtKB
Cellular Location
Cytoskeleton; Stress fiber; Cytosol; Cell cortex; Filopodium; Invadopodium; Microvillus; Cell junction. Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).
PTM
Phosphorylation at Ser-39 inhibits actin-binding (PubMed:8647875, PubMed:8999969). Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF (PubMed:22155786).
More Infomation

Li, Z., Shi, J., Zhang, N., Zheng, X., Jin, Y., Wen, S., ... & Gao, W. (2022). FSCN1 acts as a promising therapeutic target in the blockade of tumor cell motility: a review of its function, mechanism, and clinical significance. Journal of Cancer, 13(8), 2528.

Shi, Y., Xu, Y., Xu, Z., Wang, H., Zhang, J., Wu, Y., ... & Wang, K. (2022). TKI resistant-based prognostic immune related gene signature in LUAD, in which FSCN1 contributes to tumor progression. Cancer Letters, 532, 215583.

Tang, J., Xu, H., Liu, Q., Zheng, J., Pan, C., Li, Z., ... & Chen, L. (2021). LncRNA LOC146880 promotes esophageal squamous cell carcinoma progression via miR-328-5p/FSCN1/MAPK axis. Aging (Albany NY), 13(10), 14198.

Xu, M. L., Liu, T. C., Dong, F. X., Meng, L. X., Ling, A. X., & Liu, S. (2021). Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis. Aging (Albany NY), 13(15), 19776.

Wu, Y., Yuan, M. H., Wu, H. T., Chen, W. J., Zhang, M. L., Ye, Q. Q., ... & Zhang, G. J. (2020). MicroRNA-488 inhibits proliferation and motility of tumor cells via downregulating FSCN1, modulated by Notch3 in breast carcinomas. Cell Death & Disease, 11(10), 912.

Ou, C., Sun, Z., He, X., Li, X., Fan, S., Zheng, X., ... & Ma, J. (2020). Targeting YAP1/LINC00152/FSCN1 signaling axis prevents the progression of colorectal cancer. Advanced science, 7(3), 1901380.

Li, X., Han, X., Wei, P., Yang, J., & Sun, J. (2020). Knockdown of lncRNA CCAT1 enhances sensitivity of paclitaxel in prostate cancer via regulating miR-24-3p and FSCN1. Cancer Biology & Therapy, 21(5), 452-462.

Gao, W., Zhang, C., Li, W., Li, H., Sang, J., Zhao, Q., ... & Wang, B. (2019). Promoter methylation-regulated miR-145-5p inhibits laryngeal squamous cell carcinoma progression by targeting FSCN1. Molecular therapy, 27(2), 365-379.

Shen, S. N., Li, K., Liu, Y., Yang, C. L., He, C. Y., & Wang, H. R. (2019). Retracted: Down‐regulation of long noncoding RNA PVT 1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via micro RNA‐145‐mediated inhibition of FSCN 1. Molecular oncology, 13(12), 2554-2573.

Gao, R., Zhang, N., Yang, J., Zhu, Y., Zhang, Z., Wang, J., ... & Bi, J. (2019). Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-β1 in bladder cancer cells. Journal of Experimental & Clinical Cancer Research, 38(1), 1-15.

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For research use only. Not intended for any clinical use.

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