FSCN1
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Full Name
Fascin Actin-Bundling Protein 1
Function
Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945).
Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945).
Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786).
Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945).
Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Cell-cell junction assembly Source: UniProtKB
Cell migration Source: UniProtKB
Cell motility Source: UniProtKB
Establishment of apical/basal cell polarity Source: UniProtKB
Establishment or maintenance of cell polarity Source: GO_Central
Microspike assembly Source: UniProtKB
Parallel actin filament bundle assembly Source: UniProtKB
Positive regulation of extracellular matrix disassembly Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of lamellipodium assembly Source: UniProtKB
Positive regulation of podosome assembly Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of microvillus assembly Source: UniProtKB
Cellular Location
Cytoskeleton; Stress fiber; Cytosol; Cell cortex; Filopodium; Invadopodium; Microvillus; Cell junction. Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).
PTM
Phosphorylation at Ser-39 inhibits actin-binding (PubMed:8647875, PubMed:8999969). Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF (PubMed:22155786).
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Datasheet