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Mouse Anti-FRZB Recombinant Antibody (CBXS-0020) (CBMAB-S3025-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0020
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 5% trehalose, 40% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
frizzled-related protein
Introduction
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
Entrez Gene ID
2487
UniProt ID
Q92765
Alternative Names
Frizzled Related Protein; Secreted Frizzled-Related Protein 3; Frizzled-Related Protein 1; Frezzled; FRZB-1; SFRP-3; FRITZ; FRZB1; SFRP3; FRE; Frizzled Homolog-Related;
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Biological Process
Canonical Wnt signaling pathway Source: GO_Central
Cochlea morphogenesis Source: Ensembl
Convergent extension involved in organogenesis Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB
Negative regulation of cartilage development Source: Ensembl
Negative regulation of cell development Source: Ensembl
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of hepatocyte differentiation Source: Ensembl
Negative regulation of Wnt signaling pathway Source: UniProtKB
Neural crest cell differentiation Source: Ensembl
Positive regulation of apoptotic process Source: MGI
Positive regulation of fat cell differentiation Source: MGI
Skeletal system development Source: ProtInc
Somite development Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Osteoarthritis 1 (OS1):
A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement.
More Infomation

Tuerlings, M., van Hoolwerff, M., van Bokkum, J. M., Suchiman, H. E. D., Lakenberg, N., Broekhuis, D., ... & Meulenbelt, I. (2022). Long non-coding RNA expression profiling of subchondral bone reveals AC005165. 1 modifying FRZB expression during osteoarthritis. Rheumatology, 61(7), 3023-3032.

Xu, R., Zhang, F., Lu, J., Wang, K., Pan, P., Sun, Y., & Zhang, Y. (2021). Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip. Aging (Albany NY), 13(8), 11281.

Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., ... & Karperien, M. (2021). The expressions of Dickkopf-related protein 1 and frizzled-related protein are negatively correlated to local inflammation and osteoarthritis severity. Cartilage, 12(4), 496-504.

Casas-Fraile, L., Cornelis, F. M., Costamagna, D., Rico, A., Duelen, R., Sampaolesi, M. M., ... & Sáenz, A. (2020). Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels. Orphanet Journal of Rare Diseases, 15(1), 1-18.

Kwan, T., Kazamel, M., Thoenes, K., Si, Y., Jiang, N., & King, P. H. (2020). Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis. Scientific reports, 10(1), 16679.

Claudel, M., Jouzeau, J. Y., & Cailotto, F. (2019). Secreted Frizzled‐related proteins (sFRPs) in osteo‐articular diseases: much more than simple antagonists of Wnt signaling?. The FEBS Journal, 286(24), 4832-4851.

Casas-Fraile, L., Cornelis, F. M., Costamagna, D., Rico, A., Sampaolesi, M., de Munain, A. L., ... & Lories, R. J. (2018). Effect of frizzled related protein (FRZB) on muscles: an inverse relationship between FRZB and calpain-3 with potential impact on muscle dystrophy and osteoarthritis. Osteoarthritis and Cartilage, 26, S401.

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M., & Struglics, A. (2018). Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis. Osteoarthritis and cartilage, 26(6), 834-843.

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For research use only. Not intended for any clinical use.

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