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Mouse Anti-FOXJ2 Recombinant Antibody (1C3) (CBMAB-A3115-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C3
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
FOXJ2 (NP_060886.1, 475 a.a. ~ 574 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
FOXJ2
Entrez Gene ID
55810
UniProt ID
Q9P0K8
Alternative Names
FHX
Function
Isoform FOXJ2.L:
Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786).

Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity).

Isoform FOXJ2.S:
Transcriptional activator.
Biological Process
Cell differentiation Source: UniProtKB-KW
Male meiosis I Source: UniProtKB
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of blood vessel endothelial cell differentiation Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: UniProtKB
Cellular Location
Nucleus
More Infomation

Li, W., Pang, H., & Xie, L. (2023). Depletion of circ_0006459 protects human brain microvascular endothelial cells from oxygen-glucose deprivation-induced damage through the miR-940/FOXJ2 pathway. Transplant Immunology, 101780.

Bai, F. R., Wu, Q. Q., Wu, Y. J., Hu, Y. Q., Jiang, Z. X., Lv, H., ... & Wu, J. W. (2022). Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation. Cell Death & Disease, 13(7), 665.

Guo, G., & Zhu, L. (2022). FOXJ2 Inhibits the Proliferation, Migration and Epithelial-Mesenchymal Transition of Prostate Carcinoma Cells. Annals of Clinical & Laboratory Science, 52(5), 731-740.

Hiwasa, T., Wang, H., Goto, K. I., Mine, S., Machida, T., Kobayashi, E., ... & Iwadate, Y. (2021). Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke. BMC medicine, 19(1), 1-25.

Wang, C. P., Yu, Y. Z., Zhao, H., Xie, L. J., Wang, Q. T., Wang, Y., & Mu, Q. (2021). MicroRNA‑454‑5p promotes breast cancer progression by inducing epithelial‑mesenchymal transition via targeting the FoxJ2/E‑cadherin axis. Oncology Reports, 46(1), 1-11.

Tang, Y., Zhou, M., Huang, R., Shen, L., Yang, L., Zhou, Z., ... & Bai, Y. (2021). Involvement of HECTD1 in LPS-induced astrocyte activation via σ-1R-JNK/p38-FOXJ2 axis. Cell & Bioscience, 11, 1-13.

Li, Y., Zhu, X., Liu, C., Han, Q., Chen, X., Liu, Y., ... & Xia, F. (2021). Low FOXJ2 expression is associated with unfavorable postoperative prognosis of patients with epithelial ovarian cancer. Medicine, 100(10).

Bai, F. R., Wu, Q. Q., Wu, Y. J., Fu, L., Hu, Y. Q., Jiang, Z. X., ... & Wu, J. W. (2021). Impact of overexpressed FOXJ2 on mouse spermatogenesis and its action mechanism. Zhonghua nan ke xue= National Journal of Andrology, 27(7), 579-588.

Qiang, Y., Feng, L., Wang, G., Liu, J., Zhang, J., Xiang, L., ... & Chen, E. (2020). miR-20a/Foxj2 axis mediates growth and metastasis of colorectal cancer cells as identified by integrated analysis. Medical science monitor: international medical journal of experimental and clinical research, 26, e923559-1.

Zhang, H., Tang, Q. F., Sun, M. Y., Zhang, C. Y., Zhu, J. Y., Shen, Y. L., ... & Zhang, H. (2018). ARHGAP9 suppresses the migration and invasion of hepatocellular carcinoma cells through up-regulating FOXJ2/E-cadherin. Cell Death & Disease, 9(9), 916.

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For research use only. Not intended for any clinical use.

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