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Mouse Anti-FKBP4 Recombinant Antibody (CBXF-0710) (CBMAB-F2375-CQ)


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Summary

Host Animal
Mouse
Specificity
Rabbit
Clone
CBXF-0710
Antibody Isotype
IgG1
Application
ELISA, ICC, IHC, IP, RIA, WB

Basic Information

Specificity
Rabbit
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 50% glycerol, 0.1 mM PMSF
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FK506 Binding Protein 4
Introduction
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
Entrez Gene ID
100009148
UniProt ID
P27124
Alternative Names
FK506 Binding Protein 4; FK506 Binding Protein 4, 59kDa; EC 5.2.1.8; Rotamase; FKBP51; FKBP52; FKBP59; HBI; Peptidyl-Prolyl Cis-Trans Isomerase FKBP4; T-Cell FK506-Binding Protein, 59kD; Peptidylprolyl Cis-Trans Isomerase; FK506-Binding Protein 4 (59kD); 51 KDa FK506-Binding Protein; 52 KDa FK506-Binding Protein;
Function
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Biological Process
Chaperone-mediated protein folding Source: UniProtKB
Copper ion transport Source: Ensembl
Negative regulation of microtubule polymerization Source: Ensembl
Negative regulation of microtubule polymerization or depolymerization Source: UniProtKB
Negative regulation of neuron projection development Source: UniProtKB
Protein folding Source: ProtInc
Protein peptidyl-prolyl isomerization Source: GO_Central
Cellular Location
Nucleus; Cytosol; Cytoskeleton; Mitochondrion; Axon. Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity).
PTM
Phosphorylation by CK2 results in loss of HSP90 binding activity.
More Infomation

Liu, M., & Gao, N. (2021). KDM5D inhibits the transcriptional activation of FKBP4 by suppressing the expression of E2F1 in colorectal cancer in males. Biochemical Pharmacology, 194, 114814.

Chambraud, B., Daguinot, C., Guillemeau, K., Genet, M., Dounane, O., Meduri, G., ... & Giustiniani, J. (2021). Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. Autophagy, 17(11), 3491-3510.

Zong, S., Jiao, Y., Liu, X., Mu, W., Yuan, X., Qu, Y., ... & Zhao, Y. (2021). FKBP4 integrates FKBP4/Hsp90/IKK with FKBP4/Hsp70/RelA complex to promote lung adenocarcinoma progression via IKK/NF-κB signaling. Cell Death & Disease, 12(6), 602.

Kageyama, K., Iwasaki, Y., Watanuki, Y., Niioka, K., & Daimon, M. (2021). Differential effects of Fkbp4 and Fkbp5 on regulation of the proopiomelanocortin gene in murine AtT-20 corticotroph cells. International Journal of Molecular Sciences, 22(11), 5724.

Lou, Q. Y., Li, Z., Teng, Y., Xie, Q. M., Zhang, M., Huang, S. W., ... & Zou, Y. F. (2021). Associations of FKBP4 and FKBP5 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in systemic lupus erythematosus patients. Clinical Rheumatology, 40, 167-179.

Xiong, H., Chen, Z., Zheng, W., Sun, J., Fu, Q., Teng, R., ... & Zhou, J. (2020). FKBP4 is a malignant indicator in luminal A subtype of breast cancer. Journal of Cancer, 11(7), 1727.

Meng, W., Meng, J., Jiang, H., Feng, X., Wei, D., & Ding, Q. (2020). FKBP4 accelerates malignant progression of non-small-cell lung cancer by activating the Akt/mTOR signaling pathway. Analytical Cellular Pathology, 2020.

Ilaslan, E., Markosyan, R., Sproll, P., Stevenson, B. J., Sajek, M., Sajek, M. P., ... & Kusz-Zamelczyk, K. (2020). The FKBP4 gene, encoding a regulator of the androgen receptor signaling pathway, is a novel candidate gene for androgen insensitivity syndrome. International journal of molecular sciences, 21(21), 8403.

Mangé, A., Coyaud, E., Desmetz, C., Laurent, E., Béganton, B., Coopman, P., ... & Solassol, J. (2019). FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer. Theranostics, 9(23), 7003.

Federer‐Gsponer, J. R., Quintavalle, C., Mueller, D. C., Dietsche, T., Perrina, V., Lorber, T., ... & Ruiz, C. (2018). Delineation of human prostate cancer evolution identifies chromothripsis as a polyclonal event and FKBP4 as a potential driver of castration resistance. The Journal of pathology, 245(1), 74-84.

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For research use only. Not intended for any clinical use.

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