Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

FKBP4 Matched Antibody Pair (446) (APMAB-446LY)

Online Inquiry

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-FKBP4 polyclonal antibody, 100 ug
Detection Antibody
Anti-FKBP4 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Alternative Names
FK506 Binding Protein 4; FK506 Binding Protein 4, 59kDa; EC 5.2.1.8; Rotamase; FKBP51; FKBP52; FKBP59; HBI; Peptidyl-Prolyl Cis-Trans Isomerase FKBP4; T-Cell FK506-Binding Protein, 59kD; Peptidylprolyl Cis-Trans Isomerase; FK506-Binding Protein 4 (59kD); 51 KDa FK506-Binding Protein; 52 KDa FK506-Binding Protein;
Entrez Gene ID
UniProt ID
More Infomation

Liu, M., & Gao, N. (2021). KDM5D inhibits the transcriptional activation of FKBP4 by suppressing the expression of E2F1 in colorectal cancer in males. Biochemical Pharmacology, 194, 114814.

Chambraud, B., Daguinot, C., Guillemeau, K., Genet, M., Dounane, O., Meduri, G., ... & Giustiniani, J. (2021). Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. Autophagy, 17(11), 3491-3510.

Zong, S., Jiao, Y., Liu, X., Mu, W., Yuan, X., Qu, Y., ... & Zhao, Y. (2021). FKBP4 integrates FKBP4/Hsp90/IKK with FKBP4/Hsp70/RelA complex to promote lung adenocarcinoma progression via IKK/NF-κB signaling. Cell Death & Disease, 12(6), 602.

Kageyama, K., Iwasaki, Y., Watanuki, Y., Niioka, K., & Daimon, M. (2021). Differential effects of Fkbp4 and Fkbp5 on regulation of the proopiomelanocortin gene in murine AtT-20 corticotroph cells. International Journal of Molecular Sciences, 22(11), 5724.

Lou, Q. Y., Li, Z., Teng, Y., Xie, Q. M., Zhang, M., Huang, S. W., ... & Zou, Y. F. (2021). Associations of FKBP4 and FKBP5 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in systemic lupus erythematosus patients. Clinical Rheumatology, 40, 167-179.

Xiong, H., Chen, Z., Zheng, W., Sun, J., Fu, Q., Teng, R., ... & Zhou, J. (2020). FKBP4 is a malignant indicator in luminal A subtype of breast cancer. Journal of Cancer, 11(7), 1727.

Meng, W., Meng, J., Jiang, H., Feng, X., Wei, D., & Ding, Q. (2020). FKBP4 accelerates malignant progression of non-small-cell lung cancer by activating the Akt/mTOR signaling pathway. Analytical Cellular Pathology, 2020.

Ilaslan, E., Markosyan, R., Sproll, P., Stevenson, B. J., Sajek, M., Sajek, M. P., ... & Kusz-Zamelczyk, K. (2020). The FKBP4 gene, encoding a regulator of the androgen receptor signaling pathway, is a novel candidate gene for androgen insensitivity syndrome. International journal of molecular sciences, 21(21), 8403.

Mangé, A., Coyaud, E., Desmetz, C., Laurent, E., Béganton, B., Coopman, P., ... & Solassol, J. (2019). FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer. Theranostics, 9(23), 7003.

Federer‐Gsponer, J. R., Quintavalle, C., Mueller, D. C., Dietsche, T., Perrina, V., Lorber, T., ... & Ruiz, C. (2018). Delineation of human prostate cancer evolution identifies chromothripsis as a polyclonal event and FKBP4 as a potential driver of castration resistance. The Journal of pathology, 245(1), 74-84.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used FKBP4 Matched Antibody Pair (446)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Online Inquiry