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Rabbit Anti-FABP7 Recombinant Antibody (D8N3N) (CBMAB-CP0669-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
D8N3N
Antibody Isotype
IgG
Application
WB, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val84 of human FABP7 protein.
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fatty Acid Binding Protein 7
Introduction
The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]
Entrez Gene ID
Human2173
Rat80841
UniProt ID
HumanO15540
RatP55051
Alternative Names
Fatty Acid Binding Protein 7; Brain-Type Fatty Acid-Binding Protein; Brain Lipid-Binding Protein; B-FABP; FABPB; BLBP; MRG; Mammary-Derived Growth Inhibitor-Related;
Research Area
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).
Biological Process
Epithelial cell proliferation Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Nervous system development Source: ProtInc
Cellular Location
Cytoplasm
More Infomation

Zeng, F., Luo, L., Song, M., & Li, D. (2022). Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis. Journal of Receptors and Signal Transduction, 42(2), 141-150.

Nowowiejska, J., Baran, A., Hermanowicz, J. M., Sieklucka, B., Krahel, J. A., Kiluk, P., ... & Flisiak, I. (2022). Fatty Acid-Binding Protein 7 (FABP-7), Glutamic Acid and Neurofilament Light Chain (NFL) as Potential Markers of Neurodegenerative Disorders in Psoriatic Patients—A Pilot Study. Journal of clinical medicine, 11(9), 2430.

Umaru, B. A., Kagawa, Y., Shil, S. K., Arakawa, N., Pan, Y., Miyazaki, H., ... & Owada, Y. (2021). Ligand bound fatty acid binding protein 7 (FABP7) drives melanoma cell proliferation via modulation of wnt/β-catenin signaling. Pharmaceutical research, 38(3), 479-490.

Choi, W. S., Xu, X., Goruk, S., Wang, Y., Patel, S., Chow, M., ... & Godbout, R. (2021). FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells. Nutrients, 13(8), 2664.

Chen, J., Liu, X., Zhang, S., Chen, J., Sun, H., Zhang, L., & Zhang, Q. (2020). Molecular mechanism with regard to the binding selectivity of inhibitors toward FABP5 and FABP7 explored by multiple short molecular dynamics simulations and free energy analyses. Physical Chemistry Chemical Physics, 22(4), 2262-2275.

Killoy, K. M., Harlan, B. A., Pehar, M., & Vargas, M. R. (2020). FABP7 upregulation induces a neurotoxic phenotype in astrocytes. Glia, 68(12), 2693-2704.

Kagawa, Y., Umaru, B. A., Ariful, I., Shil, S. K., Miyazaki, H., Yamamoto, Y., ... & Owada, Y. (2019). Role of FABP7 in tumor cell signaling. Advances in biological regulation, 71, 206-218.

Cordero, A., Kanojia, D., Miska, J., Panek, W. K., Xiao, A., Han, Y., ... & Lesniak, M. S. (2019). FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis. Oncogene, 38(37), 6445-6460.

Islam, A., Kagawa, Y., Miyazaki, H., Shil, S. K., Umaru, B. A., Yasumoto, Y., ... & Owada, Y. (2019). FABP7 protects astrocytes against ROS toxicity via lipid droplet formation. Molecular Neurobiology, 56(8), 5763-5779.

Yasumoto, Y., Miyazaki, H., Ogata, M., Kagawa, Y., Yamamoto, Y., Islam, A., ... & Owada, Y. (2018). Glial fatty acid-binding protein 7 (FABP7) regulates neuronal leptin sensitivity in the hypothalamic arcuate nucleus. Molecular Neurobiology, 55(12), 9016-9028.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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