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Mouse Anti-FABP7 Recombinant Antibody (1H8) (CBMAB-A2804-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1H8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FABP7 (AAH12299.1, 1 a.a. ~ 132 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fatty Acid Binding Protein 7
Introduction
The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. [provided by RefSeq]
Entrez Gene ID
2173
UniProt ID
O15540
Alternative Names
B-FABP; BLBP; DKFZp547J2313; FABPB; MRG
Research Area
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).
Biological Process
Epithelial cell proliferation Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Nervous system development Source: ProtInc
Cellular Location
Cytoplasm
More Infomation

Zeng, F., Luo, L., Song, M., & Li, D. (2022). Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis. Journal of Receptors and Signal Transduction, 42(2), 141-150.

Nowowiejska, J., Baran, A., Hermanowicz, J. M., Sieklucka, B., Krahel, J. A., Kiluk, P., ... & Flisiak, I. (2022). Fatty Acid-Binding Protein 7 (FABP-7), Glutamic Acid and Neurofilament Light Chain (NFL) as Potential Markers of Neurodegenerative Disorders in Psoriatic Patients—A Pilot Study. Journal of clinical medicine, 11(9), 2430.

Umaru, B. A., Kagawa, Y., Shil, S. K., Arakawa, N., Pan, Y., Miyazaki, H., ... & Owada, Y. (2021). Ligand bound fatty acid binding protein 7 (FABP7) drives melanoma cell proliferation via modulation of wnt/β-catenin signaling. Pharmaceutical research, 38(3), 479-490.

Choi, W. S., Xu, X., Goruk, S., Wang, Y., Patel, S., Chow, M., ... & Godbout, R. (2021). FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells. Nutrients, 13(8), 2664.

Chen, J., Liu, X., Zhang, S., Chen, J., Sun, H., Zhang, L., & Zhang, Q. (2020). Molecular mechanism with regard to the binding selectivity of inhibitors toward FABP5 and FABP7 explored by multiple short molecular dynamics simulations and free energy analyses. Physical Chemistry Chemical Physics, 22(4), 2262-2275.

Killoy, K. M., Harlan, B. A., Pehar, M., & Vargas, M. R. (2020). FABP7 upregulation induces a neurotoxic phenotype in astrocytes. Glia, 68(12), 2693-2704.

Kagawa, Y., Umaru, B. A., Ariful, I., Shil, S. K., Miyazaki, H., Yamamoto, Y., ... & Owada, Y. (2019). Role of FABP7 in tumor cell signaling. Advances in biological regulation, 71, 206-218.

Cordero, A., Kanojia, D., Miska, J., Panek, W. K., Xiao, A., Han, Y., ... & Lesniak, M. S. (2019). FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis. Oncogene, 38(37), 6445-6460.

Islam, A., Kagawa, Y., Miyazaki, H., Shil, S. K., Umaru, B. A., Yasumoto, Y., ... & Owada, Y. (2019). FABP7 protects astrocytes against ROS toxicity via lipid droplet formation. Molecular Neurobiology, 56(8), 5763-5779.

Yasumoto, Y., Miyazaki, H., Ogata, M., Kagawa, Y., Yamamoto, Y., Islam, A., ... & Owada, Y. (2018). Glial fatty acid-binding protein 7 (FABP7) regulates neuronal leptin sensitivity in the hypothalamic arcuate nucleus. Molecular Neurobiology, 55(12), 9016-9028.

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For research use only. Not intended for any clinical use.

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