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Mouse Anti-EXOC4 (AA 1-109) Recombinant Antibody (CBFYE-1385) (CBMAB-E2003-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYE-1385
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-110 from human EXOC4 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-109

Target

Full Name
exocyst complex component 4
Introduction
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Entrez Gene ID
Human60412
Mouse20336
Rat116654
UniProt ID
HumanQ96A65
MouseO35382
RatQ62824
Alternative Names
Exocyst Complex Component 4; Exocyst Complex Component Sec8; SEC8L1; SEC8; SEC8-Like 1 (S. Cerevisiae); SEC8-Like 1; KIAA1699; Sec8p
Research Area
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Biological Process
Chemical synaptic transmission Source: GO_Central
Exocytosis Source: GO_Central
Golgi to plasma membrane transport Source: GO_Central
Paraxial mesoderm formation Source: Ensembl
Protein transport Source: UniProtKB-KW
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Vesicle docking involved in exocytosis Source: InterPro
Vesicle tethering involved in exocytosis Source: InterPro
Cellular Location
Midbody ring; Cell projection. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). Localizes at the leading edge of migrating cells (By similarity).
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For research use only. Not intended for any clinical use.

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