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Mouse Anti-ERP44 Recombinant Antibody (CBYJT-1240) (CBMAB-T0255-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1240
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC, IP, WB

Basic Information

Immunogen
Recombinant corresponding to aa30-407 from human TXNDC4 with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 30-407

Target

Full Name
Endoplasmic Reticulum Protein 44
Introduction
ERP44 is a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. ERP44 plays a role as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface.
Entrez Gene ID
23071
UniProt ID
Q9BS26
Alternative Names
Endoplasmic Reticulum Protein 44; Thioredoxin Domain Containing 4 (Endoplasmic Reticulum); Protein Disulfide Isomerase Family A, Member 10; Thioredoxin Domain-Containing Protein 4; ER Protein 44; TXNDC4
Research Area
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.
Biological Process
Cell redox homeostasis Source: UniProtKB
Glycoprotein metabolic process Source: UniProtKB
Protein folding Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Response to unfolded protein Source: UniProtKB
Cellular Location
Endoplasmic reticulum lumen
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For research use only. Not intended for any clinical use.

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