Rat Anti-EMB Recombinant Antibody (G7.43.1) (CBMAB-E0323-FY)

Name: Rat Anti-EMB Recombinant Antibody (G7.43.1)
SKU: CBMAB-E0323-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rat

Specificity

Mouse

Clone

G7.43.1

Antibody Isotype

IgG2b, κ

Application

FC, IHC-Fr

Basic Information

Specificity

Mouse

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

0.09% Sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

embigin homolog (mouse)

Introduction

This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1.

Entrez Gene ID

13723

UniProt ID

P21995

Alternative Names

Gp70; AL022799

Research Area

Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).

Biological Process

Axon guidance Source: GO_Central
Dendrite self-avoidance Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Plasma membrane lactate transport Source: UniProtKB

Cellular Location

Cell membrane; Synapse. Localizes to the neuromuscular junctions.

Topology

Extracellular: 33-260
Helical: 261-281
Cytoplasmic: 282-327

More Infomation

References

Sipilä, K., Rognoni, E., Jokinen, J., Tewary, M., Rudan, M. V., Talvi, S., ... & Watt, F. M. (2022). Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism. Developmental Cell.

Talvi, S., Jokinen, J., Sipilä, K., Rappu, P., Zhang, F. P., Poutanen, M., ... & Heino, J. (2021). Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality. bioRxiv.

Zhou, J., Ma, C., Wang, K., Li, X., Zhang, H., Chen, J., ... & Shi, Y. (2020). Rare and common variants analysis of the EMB gene in patients with schizophrenia. BMC psychiatry, 20(1), 1-11.

Ruma, I. M. W., Kinoshita, R., Tomonobu, N., Inoue, Y., Kondo, E., Yamauchi, A., ... & Sakaguchi, M. (2018). Embigin promotes prostate cancer progression by S100A4-dependent and-independent mechanisms. Cancers, 10(7), 239.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-EMB Recombinant Antibody (CBFYE-0155)

Mouse Anti-EMB (AA 1-327) Recombinant Antibody (CBFYE-0811)

Mouse Anti-EMB Recombinant Antibody (3F12)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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Second antibody and isotype control

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