Mouse Anti-EMB Recombinant Antibody (3F12) (CBMAB-A2580-LY)

Name: Mouse Anti-EMB Recombinant Antibody (3F12)
SKU: CBMAB-A2580-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

3F12

Antibody Isotype

IgG1, κ

Application

WB, ELISA

Basic Information

Immunogen

EMB (NP_940851.1, 1 a.a. ~ 327 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

embigin homolog (mouse)

Introduction

This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq]

Entrez Gene ID

133418

UniProt ID

Q6PCB8

Alternative Names

MGC71745

Research Area

Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).

Biological Process

Axon guidance Source: GO_Central
Dendrite self-avoidance Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Plasma membrane lactate transport Source: UniProtKB

Cellular Location

Cell membrane; Synapse. Localizes to the neuromuscular junctions.

Topology

Extracellular: 33-260
Helical: 261-281
Cytoplasmic: 282-327

More Infomation

References

Sipilä, K., Rognoni, E., Jokinen, J., Tewary, M., Rudan, M. V., Talvi, S., ... & Watt, F. M. (2022). Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism. Developmental Cell.

Talvi, S., Jokinen, J., Sipilä, K., Rappu, P., Zhang, F. P., Poutanen, M., ... & Heino, J. (2021). Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality. bioRxiv.

Zhou, J., Ma, C., Wang, K., Li, X., Zhang, H., Chen, J., ... & Shi, Y. (2020). Rare and common variants analysis of the EMB gene in patients with schizophrenia. BMC psychiatry, 20(1), 1-11.

Ruma, I. M. W., Kinoshita, R., Tomonobu, N., Inoue, Y., Kondo, E., Yamauchi, A., ... & Sakaguchi, M. (2018). Embigin promotes prostate cancer progression by S100A4-dependent and-independent mechanisms. Cancers, 10(7), 239.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-EMB (AA 1-327) Recombinant Antibody (CBFYE-0811)

Rat Anti-EMB Recombinant Antibody (G7.43.1)

Mouse Anti-EMB Recombinant Antibody (CBFYE-0155)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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