Mouse Anti-ELF2 Recombinant Antibody (CBFYE-0766) (CBMAB-E1210-FY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYE-0766

Antibody Isotype

IgG1

Application

DB, WB

Basic Information

Immunogen

Partial sequence of recombinant full-length protein to human ELF2

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

ELF2

Introduction

ELF2 (E74 Like ETS Transcription Factor 2) is a Protein Coding gene. Diseases associated with ELF2 include Peroneal Neuropathy and Nerve Compression Syndrome. Among its related pathways are Immune response IL-23 signaling pathway and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ELF1.

Entrez Gene ID

1998

UniProt ID

Q15723

Alternative Names

E74 Like ETS Transcription Factor 2; E74-Like Factor 2 (Ets Domain Transcription Factor); NERF; ETS-Related Transcription Factor Elf-2; Ets Family Transcription Factor ELF2C; New Ets-Related Factor; New ETS-Related Factor

Research Area

Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.

Isoform 2 may function in repression of RUNX1-mediated transactivation.

Biological Process

Cell differentiation Source: GO_Central
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Nucleus

More Infomation

References

Qi, X., Chen, D., Yu, W., Wang, L., Liu, L., & Tao, X. (2022). Long non-coding RNA PRNCR1 promotes ovarian cancer cell proliferation, migration and invasion by targeting the miR-653-5p/ELF2 axis. Molecular and Cellular Biochemistry, 477(5), 1463-1475.

Ma, X., & Li, Y. (2022). Circ_0028007 Aggravates the Malignancy of Nasopharyngeal Carcinoma by Regulating miR-656-3p/ELF2 Axis. Biochemical Genetics, 1-18.

Li, M., Li, Y., & Yu, M. (2020). CircRNA ZNF609 knockdown suppresses cell growth via modulating miR-188/ELF2 axis in nasopharyngeal carcinoma. OncoTargets and therapy, 13, 2399.

Zhang, W., Xu, C., Guo, J., Guo, L., Huo, H., & Wang, H. (2020). Circ-ELF2 acts as a competing endogenous RNA to facilitate glioma cell proliferation and aggressiveness by targeting MiR-510-5p/MUC15 signaling. OncoTargets and therapy, 13, 10087.

Jia, C. C., Du, J., Liu, X., Jiang, R., Huang, Y., Wang, T., ... & Wang, B. (2018). B-cell receptor-associated protein 31 regulates the expression of valosin-containing protein through Elf2. Cellular Physiology and Biochemistry, 51(4), 1799-1814.

Ahmad, H., Requena, T., Frejo, L., Cobo, M., Gallego-Martinez, A., Martin, F., ... & Bronstein, A. M. (2018). Clinical and functional characterization of a missense ELF2 variant in a CANVAS family. Frontiers in genetics, 9, 85.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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