Mouse Anti-EFNA4 Recombinant Antibody (CBFYE-0496) (CBMAB-E0849-FY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYE-0496

Antibody Isotype

IgG2

Application

Basic Information

Immunogen

Recombinant protein corresponding to human Ephrin-A4

Specificity

Human

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Ephrin A4

Introduction

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.

Entrez Gene ID

1945

UniProt ID

P52798

Alternative Names

Ephrin A4; Ephrin-A4; LERK-4; EPLG4; LERK4; Eph-Related Receptor Tyrosine Kinase Ligand 4; EPH-Related Receptor Tyrosine Kinase Ligand 4; Ligand Of Eph-Related Kinase 4; EFL4

Research Area

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

Biological Process

Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: GO_Central

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Secreted

More Infomation

References

Zhao, X., Chen, Y., Sun, X., He, Z., Wu, T., Wu, C., ... & Liu, X. S. (2022). Oncogenic EFNA4 amplification promotes lung adenocarcinoma lymph node metastasis. Cancers, 14(17), 4226.

Rowe, D. W., Hong, S. H., Zhang, C., Shin, D. G., Adams, D. J., Youngstrom, D. W., ... & Maye, P. (2021). Skeletal screening IMPC/KOMP using μCT and computer automated cryohistology: application to the Efna4 KO mouse line. Bone, 144, 115688.

Lin, J., Zeng, C., Zhang, J., Song, Z., Qi, N., Liu, X., ... & Chen, F. (2021). EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop. Molecular Therapy-Nucleic Acids, 25, 328-341.

Garrido‐Laguna, I., Krop, I., Burris III, H. A., Hamilton, E., Braiteh, F., Weise, A. M., ... & Hong, D. S. (2019). First‐in‐human, phase I study of PF‐06647263, an anti‐EFNA4 calicheamicin antibody–drug conjugate, in patients with advanced solid tumors. International journal of cancer, 145(7), 1798-1808.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rat Anti-EFNA4 Monoclonal Antibody (8K23)

Rat Anti-EFNA4 Recombinant Antibody (CBFYE-0497)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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