Rat Anti-EFNA4 Monoclonal Antibody (8K23) (CBMAB-1181-YC)

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Datasheet

Summary

Host Animal

Rat

Specificity

Mouse

Clone

8K23

Antibody Isotype

IgG2

Application

Basic Information

Immunogen

Mouse recombinant protein Ephrin-A4

Specificity

Mouse

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Ephrin A4

Introduction

Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. EFNA4 is a member of the ephrin (EPH) family, which have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis.

Entrez Gene ID

13639

UniProt ID

O08542

Alternative Names

Epl4; EFL-4; LERK-4

Research Area

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

Biological Process

Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: GO_Central

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Secreted

More Infomation

References

Zhao, X., Chen, Y., Sun, X., He, Z., Wu, T., Wu, C., ... & Liu, X. S. (2022). Oncogenic EFNA4 amplification promotes lung adenocarcinoma lymph node metastasis. Cancers, 14(17), 4226.

Rowe, D. W., Hong, S. H., Zhang, C., Shin, D. G., Adams, D. J., Youngstrom, D. W., ... & Maye, P. (2021). Skeletal screening IMPC/KOMP using μCT and computer automated cryohistology: application to the Efna4 KO mouse line. Bone, 144, 115688.

Lin, J., Zeng, C., Zhang, J., Song, Z., Qi, N., Liu, X., ... & Chen, F. (2021). EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop. Molecular Therapy-Nucleic Acids, 25, 328-341.

Garrido‐Laguna, I., Krop, I., Burris III, H. A., Hamilton, E., Braiteh, F., Weise, A. M., ... & Hong, D. S. (2019). First‐in‐human, phase I study of PF‐06647263, an anti‐EFNA4 calicheamicin antibody–drug conjugate, in patients with advanced solid tumors. International journal of cancer, 145(7), 1798-1808.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-EFNA4 Recombinant Antibody (CBFYE-0496)

Rat Anti-EFNA4 Recombinant Antibody (CBFYE-0497)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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